Influence of Aging on Severity and Anti-Inflammatory Treatment of Experimental Dry Eye Disease

Klinische Monatsblätter für Augenheilkunde
P StevenUta Gehlsen

Abstract

Purpose Aging is an important factor in dry-eye disease that has not been studied in the context of therapeutic measures. Aging-associated modifications of the ocular immune system implicate that anti-inflammatory therapies may act differently among younger individuals in terms of onset and effect of different substances. The goal of this study was to determine differences in clinical phenotype and topical anti-inflammatory therapy using a desiccating stress mouse model.MethodsAn experimental dry-eye disease (desiccating stress model) was induced in 12-week and 12-month-old female BALB/c mice. Topical therapy included 0.05% cyclosporine/F4H5 (Novaliq), F4H5, 0.05% cyclosporine (Restasis®, Allergan) and dexamethasone (Monodex®, Thea Pharma) for 3 consecutive weeks. A control group received no therapy whatsoever. Readout parameters included tear secretion, corneal fluorescein staining at 5 timepoints and histological analysis of goblet cell count at the end of the experiments.ResultsThe older mice demonstrated a significantly stronger dry eye phenotype than the younger mice. Following therapy, the older mice responded to topical anti-inflammatory therapy significantly later than the younger individuals. Regarding the different su...Continue Reading

Citations

Jun 12, 2020·Journal of Clinical Biochemistry and Nutrition·Tatsuharu ShimokawaKentaro Kogure

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