Influence of AIF1 Gene Polymorphisms on Long-Term Kidney Allograft Function

Annals of Transplantation : Quarterly of the Polish Transplantation Society
Maciej RomanowskiK Ciechanowski

Abstract

BACKGROUND Allograft inflammatory factor (AIF-1) is a recently studied cytoplasmic protein encoded by the AIF1 gene in humans. The main function of AIF-1 is in the chronic inflammatory process. The aim of this study was to examine the impact of the rs2269475: C>T, rs2736182: G>A, and rs2259571: A>C AIF1 gene polymorphisms on long-term kidney allograft function and graft loss after kidney transplantation. MATERIAL AND METHODS The study enrolled 269 white kidney allograft recipients (165 males, 104 females, mean age 47.63±12.96 years, after transplantation performed between 2000 and 2006). The rs2269475: C>T, rs2736182: G>A, and rs2259571: A>C AIF1 gene polymorphisms were genotyped with TaqMan genotyping assays using a 7500 FAST Real-Time PCR System (Applied Biosystems, USA). RESULTS Creatinine concentrations at 12, 24, 36, 48, and 60 months after transplantation did not differ significantly between the studied genotypes of AIF1 polymorphisms. Cox regression analysis showed no statistically significant associations between the risk of graft loss/return to dialysis and the examined polymorphisms. CONCLUSIONS The results of our study suggest that the AIF1 gene polymorphisms have no influence on long-term kidney allograft function.

Citations

Dec 13, 2019·Immunology Letters·Mateusz SikoraAndrzej Pawlik

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.