Influence of air pollution on airway inflammation and disease activity in childhood-systemic lupus erythematosus

Clinical Rheumatology
Andressa Guariento Ferreira AlvesSylvia Costa Lima Farhat

Abstract

Exposure to fine particles may trigger pulmonary inflammation/systemic inflammation. The objective of this study was to investigate the association between daily individual exposure to air pollutants and airway inflammation and disease activity in childhood-onset systemic lupus erythematosus (cSLE) patients. A longitudinal panel study was carried out in 108 consecutive appointments with cSLE patients without respiratory diseases. Over four consecutive weeks, daily individual measures of nitrogen dioxide (NO2), fine particulate matter (PM2.5), ambient temperature, and humidity were obtained. This cycle was repeated every 2.5 months along 1 year, and cytokines of exhaled breath condensate-EBC [interleukins (IL) 6, 8, 17 and tumoral necrose factor-α (TNF-α)], fractional exhaled NO (FeNO), and disease activity parameters were collected weekly. Specific generalized estimation equation models were used to assess the impact of these pollutants on the risk of Systemic Lupus Erythematous Disease Activity Index 2000 (SLEDAI-2K) ≥ 8, EBC cytokines, and FeNO, considering the fixed effects for repetitive measurements. The models were adjusted for inflammatory indicators, body mass index, infections, medication, and weather variables. An IQR...Continue Reading

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Citations

Apr 30, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Maria Fernanda Giacomin GoulartSylvia Costa Lima Farhat
Mar 27, 2021·Particle and Fibre Toxicology·Victor Yuji YariwakeMariana Matera Veras
Jul 11, 2021·Paediatric Drugs·Vitor Cavalcanti TrindadeClovis Artur Silva
Nov 19, 2021·Indian Journal of Pediatrics·Chen-Hao MaiChang-Ching Wei

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