Influence of albumin leakage on glycated albumin in patients with type 2 diabetes undergoing hemodialysis.

Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs
Sayo UedaJun Minakuchi

Abstract

Glycated albumin (GA) is recommended as a better glycemic indicator than HbA1c in patients undergoing hemodialysis, because the red blood cell lifespan is generally faster than that in normal subjects. However, GA can be also affected by protein loss in urine and hemodialysis fluid. Therefore, in this study, we investigated the effect of albumin leakage induced by hemodialysis on GA. Nine patients undergoing hemodialysis with a large or small amount of albumin leakage were observed for 9 months in a crossover manner. As a result, it was shown that albumin leakage could affect GA, but the effect was practically small considering the prescription of diabetic drugs. The correlations between HbA1c and blood glucose levels and between GA and blood glucose levels were similar in our study. In conclusion, GA was a reliable indicator, even with the change of hemodialysis modality. The influence of albumin leakage induced by hemodialysis on GA was negligible practically. We should recognize that the preferable glycemic indicator in patients undergoing hemodialysis depends on the hemoglobin and albumin metabolism of each patient.

References

Jun 1, 2011·Contributions to Nephrology·Francesco LocatelliGiuseppe Pontoriero
Feb 16, 2013·Journal of the American Society of Nephrology : JASN·Francisco MaduellUNKNOWN ESHOL Study Group
Mar 31, 2015·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Toshiyuki NakaoUNKNOWN Japanese Society for Dialysis Therapy
Apr 18, 2016·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Kojiro NagaiJun Minakuchi
Apr 28, 2016·International Journal of Molecular Sciences·Hiroki KobayashiKazuyoshi Okada

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