Influence of alcohol use, race, and viral coinfections on spontaneous HCV clearance in a US veteran population

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Barbara A PiaseckiKyong-Mi Chang

Abstract

Hepatitis C virus (HCV) is spontaneously cleared in 15% to 45% of individuals during primary infection. To define the role of alcohol, race, and HBV or HIV coinfections in natural HCV clearance, we examined these parameters in 203 spontaneously HCV-recovered subjects (HCV Ab(+)/RNA(-) subjects without prior antiviral therapy) and 293 chronically HCV-infected patients (HCV Ab(+)/RNA(+)). Subjects were identified from 1,454 HCV antibody-seropositive US veterans tested for HCV RNA between January 2000 and July 2002 at the Philadelphia Veterans Affairs Medical Center. In univariate analysis, alcohol use disorder (odds ratio [OR] 0.52; 95% CI, 0.31-0.85; P =.006) and black race (OR 0.65; 95% CI, 0.44-0.96; P =.024) were both associated with decreased likelihood of spontaneous HCV clearance. In multivariate analyses adjusting for race, HIV infection, age, and alcohol use disorder, alcohol remained strongly associated with reduced HCV clearance (OR 0.49; 95% CI, 0.30-0.81; P =.005). In contrast, the association between black race and viral clearance was no longer statistically significant (adjusted OR 0.72; 95% CI, 0.48-1.09; P =.125). HIV coinfection was negatively associated with HCV clearance (OR 0.37; 95% CI, 0.16-0.83; P =.016), ...Continue Reading

Citations

Feb 18, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Amy C JusticeUNKNOWN VACS Project Team
Oct 6, 2005·Blood·Mingdong ZhangUNKNOWN Second Multicenter Hemophilia Cohort Study
Aug 7, 2008·Journal of Addictive Diseases·Jason GrebelyBrian Conway
Oct 30, 2012·Future Virology·Eric G MeissnerShyamasundaran Kottilil
Aug 19, 2007·Journal of Clinical Gastroenterology·Ashwani K Singal, Bhupinder S Anand
Dec 14, 2005·Journal of Hepatology·Xavier Forns, Josep Costa
Jan 25, 2013·TheScientificWorldJournal·Mohamed A DawMohamed M Agnan
Aug 19, 2014·BioMed Research International·Fei KongJunqi Niu
Feb 24, 2006·The American Journal of Gastroenterology·Nathan A MerrimanKyong-Mi Chang
Jul 29, 2005·Nature·William F McDonough

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