Abstract
Hepatitis C virus (HCV) is spontaneously cleared in 15% to 45% of individuals during primary infection. To define the role of alcohol, race, and HBV or HIV coinfections in natural HCV clearance, we examined these parameters in 203 spontaneously HCV-recovered subjects (HCV Ab(+)/RNA(-) subjects without prior antiviral therapy) and 293 chronically HCV-infected patients (HCV Ab(+)/RNA(+)). Subjects were identified from 1,454 HCV antibody-seropositive US veterans tested for HCV RNA between January 2000 and July 2002 at the Philadelphia Veterans Affairs Medical Center. In univariate analysis, alcohol use disorder (odds ratio [OR] 0.52; 95% CI, 0.31-0.85; P =.006) and black race (OR 0.65; 95% CI, 0.44-0.96; P =.024) were both associated with decreased likelihood of spontaneous HCV clearance. In multivariate analyses adjusting for race, HIV infection, age, and alcohol use disorder, alcohol remained strongly associated with reduced HCV clearance (OR 0.49; 95% CI, 0.30-0.81; P =.005). In contrast, the association between black race and viral clearance was no longer statistically significant (adjusted OR 0.72; 95% CI, 0.48-1.09; P =.125). HIV coinfection was negatively associated with HCV clearance (OR 0.37; 95% CI, 0.16-0.83; P =.016), ...Continue Reading
Citations
Dec 25, 2008·Journal of Gastroenterology·Yuka TakahamaHirohito Tsubouchi
Apr 9, 2005·Genes and Immunity·T K OleksykM W Smith
Feb 18, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Amy C JusticeUNKNOWN VACS Project Team
Jul 17, 2007·AIDS·Lehida Melendez-MoralesJames J Goedert
Jan 26, 2006·Gut·I BakrA Fontanet
Apr 19, 2007·Gut·Chia-Yen DaiMing-Lung Yu
Oct 6, 2005·Blood·Mingdong ZhangUNKNOWN Second Multicenter Hemophilia Cohort Study
Aug 7, 2008·Journal of Addictive Diseases·Jason GrebelyBrian Conway
Dec 30, 2006·PLoS Medicine·Arthur Y KimBruce D Walker
Sep 3, 2011·PloS One·Hossein PoustchiReza Malekzadeh
Apr 14, 2010·Molecular Medicine·Valeria R MasDaniel Maluf
Jun 14, 2014·PloS One·Jose Ramón Vidal-CastiñeiraCarlos López-Larrea
Oct 30, 2012·Future Virology·Eric G MeissnerShyamasundaran Kottilil
Jun 14, 2013·Hepatitis Research and Treatment·Joseph KluckKyong-Mi Chang
Jul 20, 2006·Medical Care·Amy C JusticeUNKNOWN VACS 3 Project Team
Aug 19, 2007·Journal of Clinical Gastroenterology·Ashwani K Singal, Bhupinder S Anand
Aug 29, 2006·Transfusion·Dirk PosthouwerEveline P Mauser-Bunschoten
Dec 14, 2005·Journal of Hepatology·Xavier Forns, Josep Costa
Jan 25, 2013·TheScientificWorldJournal·Mohamed A DawMohamed M Agnan
Aug 19, 2014·BioMed Research International·Fei KongJunqi Niu
Feb 24, 2006·The American Journal of Gastroenterology·Nathan A MerrimanKyong-Mi Chang
Jul 29, 2005·Nature·William F McDonough
Nov 23, 2016·World Journal of Hepatology·Daniel FusterRobert Muga