Influence of Alcohols on the Lateral Diffusion in Phospholipid Membranes

The Journal of Physical Chemistry. B
Simona RificiUlderico Wanderlingh

Abstract

The effects of hexanol and octanol on the lateral mobility of 1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine (DMPC) bilayer are investigated by means of pulsed-gradient stimulated-echo NMR spectroscopy. Three distinct diffusions are identified for the DMPC/alcohol systems. They are ascribed to the water, the alcohol, and the lipid. We find that the presence of alcohols promotes the lipid diffusion process both in the liquid and in the interdigitated phases. Furthermore, using the Arrhenius approach, the activation energies are calculated. An explanation in terms of a free volume model, that takes into account also the observed increase of the activation energy in both phases, is proposed. The results obtained here are compared with those presented in our previous work on 1,2-palmitoyl-sn-glycero-3-phosphocholine (DPPC) in order to examine the dependence of the lipid translational diffusion process upon the membrane acyl chain length. A peculiar influence of alcohols on different membranes is found.

References

Oct 5, 1992·Biochimica Et Biophysica Acta·J S ChiouI Ueda
Jan 1, 1988·Progress in Lipid Research·J L Slater, C H Huang
Apr 30, 2003·Biophysical Journal·Andrey FilippovGöran Lindblom
Aug 29, 2003·Biophysical Journal·Holly C Gaede, Klaus Gawrisch
Dec 6, 2005·Biophysical Journal·Michael PatraMikko Karttunen
May 13, 2006·Annual Review of Biophysics and Biomolecular Structure·Thomas J McIntosh, Sidney A Simon
Jan 16, 2007·Biophysical Journal·Allison N Dickey, Roland Faller
May 5, 2007·Rapid Communications in Mass Spectrometry : RCM·Delphine OurselCatherine M Lange
Sep 29, 2009·Trends in Neurosciences·Steven N Treistman, Gilles E Martin
Sep 8, 2010·Biophysical Journal·Sivaramakrishnan RamaduraiBert Poolman
Dec 15, 2010·Physical Chemistry Chemical Physics : PCCP·S S SarangiS Balasubramanian
Jul 7, 2011·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Martin D KayeMaikel C Rheinstädter
Dec 14, 2011·Biochimica Et Biophysica Acta·Piotr JurkiewiczMartin Hof
Dec 5, 2012·The Journal of Chemical Physics·F Y HansenA Miskowiec
May 9, 2014·The Journal of Chemical Physics·U WanderlinghH D Middendorf
Jul 19, 2014·The Journal of Physical Chemistry. B·Simona RificiUlderico Wanderlingh
Oct 30, 2014·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Valeria Conti NibaliMounir Tarek
Jun 24, 2015·Nature Reviews. Cardiology·Joaquim Fernández-Solà

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.