PMID: 1211480Dec 1, 1975Paper

Influence of altered O2 tension on substrate metabolism in perfused rat lung

The American Journal of Physiology
R A RhoadesM L Eskew

Abstract

Effects of hypoxia (1.5 h) on glucose and palmitate metabolism were investigated in perfused lungs from normal rats and rats exposed for 24 h to hypobaric conditions (simulated altitude of 24,000 ft). Hypoxic lungs were ventilated with 5% O2-5% CO2 and control lungs with 21% O2-5% CO2. Blood gases and pH remained stable during the 1.5-h perfusion period. Exposure of normal rat lungs to 1.5 h of in vitro hypoxia (blood Po2=34 mmHg) significantly increased lactate production and mean arterial pulmonary pressure, but did not alter glucose uptake, pyruvate levels, and oxidation of either [U-14C]glucose or [1-14C]palmitate to CO2. Incorporation of labeled glucose and palmitate into lung lipids was also unaltered. In contrast to normal lungs, prior exposure to hypoxia for 24 h and subsequent perfusion under hypoxic conditions significantly stimulated glucose uptake (74% increase), markedly increased glucose incorporation into lung lipids, and increased oxidation of glucose to CO2. Lactate/pyruvate ratios also showed a significant 38% increase. Lung glycogen was unchanged following 24 h hypoxia. These data indicate that adaptive changes occur in metabolic processes within the lung during acute changes in O2 tension.

Citations

Jun 1, 1984·Environmental Health Perspectives·R A Rhoades
May 29, 2009·Journal of Lipid Research·Paola E CogoVirgilio P Carnielli
Jun 17, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Matthew L JohnsonGeorge A Brooks
Jan 1, 1986·Lung·M J EngleA F Dehring
Oct 19, 1977·Pflügers Archiv : European journal of physiology·J Pérez-DíazM S Ayuso-Parrilla
Dec 1, 1978·The American Journal of Physiology·R A RhoadesS Wali
Dec 9, 1998·The American Journal of Physiology·M OzakiB E Marshall
Jul 1, 1981·The American Journal of Physiology·A B Fisher, C Dodia
Oct 1, 1978·Respiration Physiology·R A Rhoades, E G Whittle
Jan 1, 1992·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·A O AbuelgassimS M Khoja
May 1, 1981·Respiration Physiology·S S RoundsJ T Reeves

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