PMID: 64142Jan 1, 1976Paper

Influence of aminooxyacetate administration on ammonia-induced metabolic disturbances in the rat liver

Archives internationales de physiologie et de biochimie
M A PetitR Nordmann

Abstract

The purpose of the present report was to investigate the effects of aminooxyacetate administration to rats on the ammonia-induced disturbances in the substrate levels and in the activities of the enzymes involved in glutamine metabolism. 1.--Aminooxyacetate enhances the accumulation of ammonia following an ammonia load and prevents the other substrate level changes induced by ammonia. Thus, this transaminase inhibitor suppresses ammonia detoxication by formation of aminoacids as well as by urea synthesis. 2.--A significant decrease of glutamine synthetase activity is observed only after administration of both aminooxyacetate and ammonium chloride. 3.--Like in rats injected with ammonium chloride alone, an ammonia-induced activation of liver glutaminase I is found in inhibitor-pretreated rats. This result confirms the specific enhancement of glutaminase I activity by ammonia in excess.

Citations

Sep 3, 1979·Biochimica Et Biophysica Acta·E ChicoI Núñez de Castro
Oct 1, 1982·Ecotoxicology and Environmental Safety·G SchenoneP Mensi
Sep 1, 1981·Ecotoxicology and Environmental Safety·A ArilloG Schenone
Jul 1, 1981·Molecular and Cellular Biochemistry·D L DoggettB L Strehler

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