Influence of amygdaloid glutamatergic receptors on sensory and emotional pain-related behavior in the neuropathic rat

Behavioural Brain Research
Osei B AnsahAntti Pertovaara

Abstract

The role of amygdaloid glutamatergic receptors (GluRs) in maintenance of the sensory versus emotional component of neuropathic pain was studied by assessing monofilament-induced limb withdrawal response (sensory pain) and aversive place-conditioning behavior (emotional pain) following amygdaloid administration of various glutamatergic compounds in nerve-injured animals. The results indicate that endogenous activation of amygdaloid group I metabotropic GluRs, mGluR(1) and mGluR(5), and the NMDA-R contributes to maintenance of sensory and emotional components of neuropathic pain. The predominant effect by amygdaloid group I mGluRs was facilitation of emotional-like pain behavior.

References

Sep 26, 2007·The European Journal of Neuroscience·Leonor GonçalvesAntti Pertovaara

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Citations

Jan 21, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zhen LiVolker Neugebauer
Aug 26, 2014·Neuroscience and Biobehavioral Reviews·Ipek YalcinMichel Barrot
Aug 14, 2013·Molecular Pain·Stéphanie Grégoire, Volker Neugebauer
Mar 20, 2012·The Journal of Pain : Official Journal of the American Pain Society·Catherine A Spuz, George S Borszcz
Mar 23, 2011·Progress in Neurobiology·John Kealy, Sean Commins
Nov 3, 2010·Neuropharmacology·F NicolettiJ P Pin
Apr 13, 2010·Behavioural Brain Research·Megan L Uhelski, Perry N Fuchs
Jan 1, 2013·Journal of Molecular Psychiatry·Pierre VeinanteMichel Barrot
Mar 27, 2015·Neural Plasticity·Lisa DoanJing Wang
Jul 14, 2010·The Journal of Pain : Official Journal of the American Pain Society·Nora BourbiaAntti Pertovaara
Oct 8, 2013·Pharmacology, Biochemistry, and Behavior·A Vania ApkarianSoundar Regunathan
Jan 18, 2011·Brain Research·Amteshwar Singh Jaggi, Nirmal Singh
May 19, 2017·BMC Neurology·Crystal StinsonPhillip R Kramer
Jul 14, 2018·The Journal of Physiology·Sarah A Kissiwaa, Elena E Bagley
Sep 5, 2014·Current Opinion in Anaesthesiology·Ipek Yalcin, Michel Barrot

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