PMID: 8950389Oct 1, 1996Paper

Influence of androgens and pituitary hormones on the structural profile and secretory activity of the lacrimal gland

Acta Ophthalmologica Scandinavica
D A SullivanJ D Pena

Abstract

The present study was designed to examine the influence of androgens on the size, morphological appearance, and fluid and protein secretory capacity of the lacrimal gland in a variety of species. For comparison, we also sought to determine whether other hormones might stimulate the growth and secretory ability of this tissue. Lacrimal glands and tears were obtained from intact, surgically-operated and/or hormone-treated rats, mice, guinea pigs and rabbits and the processed for histological and/or image analysis techniques. Our results demonstrated that: 1) androgens modulate the ultrastructural features of rat lacrimal tissue; 2) androgens may influence the weight, morphological aspects, and secretion of the lacrimal gland, however, these effects are not uniform in mice, rats, guinea pigs and rabbits, but instead are dependent upon the species and/or the animal's endocrine status; and 3) treatment with testosterone, prolactin, growth hormone, alpha-melanocyte stimulating hormone, insulin, or thyroxine plus dexamethasone had no impact on the absolute or relative size of the lacrimal gland, or the tear volume, of hypophysectomized male rats. Overall, these findings indicate that androgens may regulate the structure and secretion ...Continue Reading

References

Jul 1, 1992·Clinical Immunology and Immunopathology·D A Sullivan, E H Sato
Apr 1, 1990·Acta Ophthalmologica·D A SullivanM R Allansmith
Dec 1, 1989·Clinical Immunology and Immunopathology·H ArigaD A Sullivan
Feb 1, 1986·Experimental Eye Research·D A Sullivan, M R Allansmith
Mar 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·J GaoD A Sullivan
Jan 1, 1994·Advances in Experimental Medicine and Biology·D A SullivanE H Sato
Feb 1, 1994·The Journal of Steroid Biochemistry and Molecular Biology·J WinderickxW Heyns
Dec 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·F J RochaD A Sullivan
Sep 1, 1958·The Anatomical Record·R WALKER
May 1, 1965·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·G QUINTARELLI, M C DELLOVO
Jun 1, 1955·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·M RADNOT, B NEMETH
Jul 1, 1945·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·R BRUCKNER

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Citations

Sep 29, 2000·Cornea·S C PflugfelderM E Stern
Dec 14, 2006·American Journal of Physiology. Endocrinology and Metabolism·Yanru WangAustin K Mircheff
Apr 3, 2014·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Susan TruongBlanka Golebiowski
Oct 24, 2018·International Journal of Molecular Sciences·Yury ChalyScott M Lieberman
Oct 31, 2006·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Gürkan UncuOsman Develioğlu
May 21, 2019·Investigative Ophthalmology & Visual Science·Mathias Kaurstad MorthenDavid A Sullivan
Nov 21, 2014·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Md Nurul IslamTakashi Yamashiro
Jun 18, 2020·International Journal of Molecular Sciences·Chang Ho YoonMee Kum Kim
Nov 27, 2009·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·F SchirraE Knop
Jul 23, 1999·Annals of the New York Academy of Sciences·D A SullivanI Toda
Oct 6, 2001·Survey of Ophthalmology·C Baudouin
Nov 29, 2005·Experimental Eye Research·Driss Zoukhri

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