PMID: 490085Aug 1, 1979Paper

Influence of androgens on the weights of the male accessory reproductive organs and on the activities of mitochondrial enzymes in the epididymis of the rat

The Journal of Endocrinology
D E Brooks

Abstract

The influence of androgens on the male accessory glands of the rat was assessed in terms of changes in weight and of the specific activity of the mitochondrial enzymes, succinate dehydrogenase, glycerolphosphate dehydrogenase and pyruvate carboxylase, in the epididymis. In some instances, the activity of the cytoplasmic enzymes, hexokinase and phosphofructokinase, was also measured and the influence of androgens on these enzymes was found to be similar to that on the mitochondrial enzymes. After the administration of androgen to castrated rats the specific activity of enzymes reached a new steady state sooner than did epididymal weight. The time taken for the specific activity of the enzymes to reach a new steady state after the removal of androgen was variable, depending on the enzyme and the region of the epididymis. This time was generally longer, however, than the time taken for induction, and in the case of glycerolphosphate dehydrogenase, the decline of activity was slower in the cauda than in the caput. In castrated animals, about 100 times as much androgen was required to attain maximum tissue weight as was required to attain maximum enzyme activity. The epididymis, prostate and seminal vesicles responded similarly to a...Continue Reading

Citations

Aug 1, 1997·Molecular Reproduction and Development·S ErgünM S Davidoff
Apr 1, 1989·Journal of Ethnopharmacology·S ManonayagiT Malini
Jun 1, 2005·Life Sciences·Elisabeth MarósticaCatarina S Porto
Aug 2, 2005·Theriogenology·M Montserrat RiveraJoan E Rodríguez-Gil
Apr 30, 2004·Biology of Reproduction·Theodore R Chauvin, Michael D Griswold
Apr 7, 2006·Biology of Reproduction·Chitra Lekha Dahia, A Jagannadha Rao
Jun 25, 2010·Molecular and Cellular Endocrinology·Erick J R SilvaMaria Christina W Avellar
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May 4, 2012·Toxicologic Pathology·Robert E Chapin, Dianne M Creasy
Apr 5, 2000·The Journal of Biological Chemistry·R W WongS Y Chan
Jun 26, 2007·Asian Journal of Andrology·Bernard RobaireSophie-Anne Lamour
May 7, 2014·The Journal of Clinical Endocrinology and Metabolism·Domenico MilardiAlfredo Pontecorvi
Feb 15, 2003·Endocrinology·Nadine Ezer, Bernard Robaire
Dec 11, 2019·Journal of Clinical Medicine·Giuseppe GrandeAlfredo Pontecorvi
Jan 12, 2021·Saudi Journal of Biological Sciences·Yasmine Asaad MansourGehad A H El-Bargeesy
May 7, 2020·Protein and Peptide Letters·Giuseppe GrandeAlfredo Pontecorvi

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