PMID: 9535153Apr 16, 1998Paper

Influence of angiotensin converting enzyme inhibition and angiotensin II type 1 receptor antagonism on renal sodium and water handling and albuminuria during infusion of atrial natriuretic factor into healthy volunteers

Journal of Hypertension
G VervoortP Smits

Abstract

Atrial natriuretic factor increases urinary sodium and water excretion. It also causes an increase in albuminuria. Angiotensin converting enzyme inhibition attenuates the effects of atrial natriuretic factor on renal sodium and water handling; however, it is not known whether this effect is mediated by the accompanied decrease in blood pressure or by suppression of the renin-angiotensin system. To test the hypothesis that atrial natriuretic factor mediates natriuresis and diuresis by inhibiting angiotensin II, by studying the effects of the angiotensin converting enzyme inhibitor enalapril and the angiotensin II type 1 receptor antagonist losartan. In addition, the effects of these drugs on atrial natriuretic factor-induced albuminuria were examined. We investigated the effects of enalapril and losartan on atrial natriuretic factor-induced changes in urinary excretion of sodium, water and albumin from eight healthy volunteers. Measurements of systemic and renal haemodynamics in these subjects were performed before and during a 2 h infusion of atrial natriuretic factor [0.01 microg/kg per min (low dose) for the first 60 min and 0.02 microg/kg per min (high dose) for the second 60 min]. Measurements were performed after 5 days of...Continue Reading

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Citations

Nov 6, 2003·Regulatory Peptides·Thomas WaltherHolger Stepan
Feb 7, 2015·European Journal of Heart Failure·Adriaan A VoorsUNKNOWN PARAMOUNT Investigators
Sep 14, 2007·Scandinavian Journal of Clinical and Laboratory Investigation·Jan Carstens, Erling Bjerregaard Pedersen
Apr 23, 1999·Pharmacotherapy·I Gavras, H Gavras

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