PMID: 8963958Jan 1, 1996Paper

Influence of angiotensin II on circulating adhesion molecules and blood leukocyte count in vivo

Canadian Journal of Physiology and Pharmacology
K KrejcyO Wagner

Abstract

The mechanism of the beneficial effect of angiotensin converting enzyme inhibitors in patients with myocardial infarction is not clear. Recent in vitro data indicate that angiotensin II (AII) stimulates the expression of adhesion molecules and thus activates leukocyte endothelial interactions. In eight healthy volunteers we investigated the influence of exogenous AII on circulating adhesion molecules and on the blood leukocyte count. A systemically effective and a systemically ineffective dose of AII were administered intravenously over 4 h in a single blind crossover design. Examination of the time course of circulating intercellular and vascular adhesion molecules and E-selectin (cICAM-1, cVCAM-1, cE-selectin-1) in response to the AII infusion revealed increases of up to 11% (especially in cVCAM-1 levels) at single time points, but no significant sustained elevation or trend that can be interpreted as a drug-induced effect. The systemically effective dose, which induced an increase in mean arterial blood pressure from 80 to 108 mmHg (1 mmHg = 133.3 Pa), resulted in a significant increase in blood leukocytes, from 4.8 +/- 0.3 to 5.5 +/- 0.3 g/L (p < 0.05); the systemically ineffective AII dose did not alter blood leukocyte cou...Continue Reading

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Citations

May 16, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Craig WongDominic Raj
Apr 25, 2001·Kidney International·B Rodríguez-IturbeR J Johnson
Nov 24, 2004·European Journal of Heart Failure·Michael D SosinGregory Y H Lip
Apr 25, 2015·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Mikael EkholmN Håkan Wallén
Aug 16, 2005·Archives of Biochemistry and Biophysics·Hong Zhang, Geng-Yun Sun
Oct 12, 2004·Journal of Cardiovascular Pharmacology·Monika GraningerBernd Jilma

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