PMID: 8581412Sep 1, 1995Paper

Influence of anti-IgG antibodies on graft outcome in live related donor renal transplantation

Transplant Immunology
M T Tahir, N K Mehra

Abstract

To study the role of pretransplant IgG anti-F(ab)2 gamma and IgG anti-Fc antibodies on the outcome of live related donor (LRD) kidney transplantation, serum samples from 60 recipients and 20 normal controls (NC) were tested using enzyme immunoassay. Patients with well-functioning grafts (WFG) after 1 year of follow-up had significantly higher IgG anti-F(ab)2 gamma activity expressed as mean optical density measured at 405 nm, i.e. 0.426 +/- 0.06 as compared to NC (0.167 +/- 0.046) or patients undergoing reversible rejection (RR) (0.145 +/- 0.043) and irreversible rejections (IR) (0.26 +/- 0.01). However, patients with IR had higher IgG anti-Fc activity (0.424 +/- 0.2) than the WFG group (0.1 +/- 0.02) and NC (0.095 +/- 0.02), with the RR group values in between (0.248 +/- 0.06). The same trend was observed when the data were analysed according to the serum creatinine levels. We conclude that in the LRD renal transplant situation, pretransplant serum IgG anti-F(ab)2 gamma activity has a protective effect on graft survival while IgG anti-Fc has a detrimental effect on graft outcome.

References

Nov 1, 1990·Immunology Letters·C SüsalG Opelz
Jan 1, 1989·International Archives of Allergy and Applied Immunology·M MiyataJ Dausset
Jul 1, 1965·The New England Journal of Medicine·M WALLERE C TOONE

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