Influence of anti-inflammatory and antioxidant agents on endothelial permeability alterations induced by bradykinin

Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research
X DengR Andersson

Abstract

Increased vascular permeability to plasma proteins and altered hemodynamics at the site of inflammation are characteristics of inflammation. In the present study, alterations in endothelial barrier permeability were evaluated in different organs/tissues 6 h after a systemic inflammatory response induced by intravenous injection of bradykinin (BK; 1.7 mg/kg). The effect of intravenous pretreatment with indomethacin or ibuprofen (cyclooxygenase inhibitors), N-acetyl-L-cysteine (NAC, an oxygen free radical scavenger), and allopurinol (a xanthine oxidase inhibitor) was determined. Endothelial permeability was evaluated by determining tissue water content (TWC), 125I-labeled human serum albumin (HSA) flux, and albumin leakage index (ALI) in various organs/tissues. The vasodilation in the local tissues was reflected by tissue blood content (TBC), measured by 51Cr-labeled red blood cells. The results indicate that albumin flux significantly increased in the peritoneum, pancreas, stomach, PSI, DSI, colon, kidneys, liver, lungs, and brain, TBC significantly increased in the kidneys, liver, lungs, and heart, as well as in the intestine, and an increased ALI, assaying endothelial permeability considering local hemodynamic alterations was ...Continue Reading

References

Jan 1, 1992·Annual Review of Pharmacology and Toxicology·S G Farmer, R M Burch
Sep 1, 1990·The Journal of Surgical Research·P D CareyH J Sugerman
Jun 1, 1985·Japanese Journal of Pharmacology·S Konno, S Tsurufuji
Feb 1, 1987·Immunopharmacology·V G Nielsen, R O Webster
Nov 1, 1987·Journal of Applied Physiology·T J StelznerJ V Weil
Nov 1, 1970·Proceedings of the Society for Experimental Biology and Medicine·G GabbianiG Majno
Feb 1, 1983·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·T SugitaJ T Reeves
Feb 1, 1993·Journal of Cardiovascular Pharmacology·W D DachmanB B Hoffman
Dec 1, 1993·Circulation·G V BedaridaB B Hoffman
Dec 1, 1993·British Journal of Pharmacology·M M TeixeiraP G Hellewell
Nov 1, 1993·Journal of Applied Physiology·H L PanJ C Longhurst
Jul 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N OharaS W Chang
Jun 1, 1993·The American Review of Respiratory Disease·T DragovićS F Rabito
May 1, 1993·Scandinavian Journal of Gastroenterology·W GuoS Bengmark

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Citations

Jun 30, 2011·Free Radical Biology & Medicine·Paul A Fraser
May 16, 2012·Respiration; International Review of Thoracic Diseases·Vasileios K KouritasChrisi Hatzoglou
Feb 26, 2009·Free Radical Research·Pamela B L PunShabbir Moochhala
Oct 22, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Sakuji ShigematsuRonald J Korthuis
Nov 16, 2021·Journal of Internal Medicine·D Lapenna

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