Influence of antibiotic pressure on multi-drug resistant Klebsiella pneumoniae colonisation in critically ill patients

Antimicrobial Resistance and Infection Control
Jesus RuizPaula Ramirez

Abstract

The aim of this study is to evaluate the risk factors for colonisation by multidrug resistant (MDR) K. pneumoniae in a critical care unit and the relationship between colonisation and the antibiotic pressure exerted by the antimicrobial treatments received by patients. A prospective observational was designed. Patients admitted for more than 48 h to an intensive care unit were included. Samples for surveillance cultures were obtained from all the patients upon admission and once a week. The association between risk factors and colonisation by MDR K. pneumoniae was determined by logistic regression. A Cox regression model was used to evaluate the effect of the use of antimicrobials on the colonisation rate. An ARMIA model was used to investigate the association between the incidence of colonisation by MDR strains and the global consumption of antimicrobials in the unit. One thousand seven hundred twenty-five patients were included, from which 308 (17.9%) were positive for MDR K. pneumoniae. In the multivariate analysis, hospitalisation for longer than 7 days together with respiratory infection and administration of any antibiotic was associated with increased MR K. pneumoniae colonisation. Patients who received antibiotics for m...Continue Reading

References

Mar 1, 1994·Antimicrobial Agents and Chemotherapy·E J Vollaard, H A Clasener
Jul 9, 2004·The Journal of Hospital Infection·C DefezA Sotto
Dec 16, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sara E Cosgrove
Aug 31, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·F DrobniewskiUNKNOWN Subcommittee on Antimicrobial Susceptibility Testing of Mycobacterium tuberculosis of the European Committee for Antimicrobi
Jan 22, 2011·Journal of Infection in Developing Countries·Kutbettin Demirdag, Salih Hosoglu
Jul 29, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A-P MagiorakosD L Monnet
Aug 24, 2013·The Lancet Infectious Diseases·L Silvia Munoz-PriceJohn P Quinn
Jul 2, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M GiannellaM Tumbarello
Jul 17, 2014·BMC Research Notes·Miroslava Htoutou SedlákováMilan Kolář
May 6, 2015·Critical Care : the Official Journal of the Critical Care Forum·Nazaret Cobos-TriguerosJosé Antonio Martínez
Oct 13, 2015·World Journal of Gastroenterology : WJG·Melissa LatorreDaniel E Freedberg
Feb 13, 2016·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Hacer AkturkNuran Salman
Jul 19, 2017·Diagnostic Microbiology and Infectious Disease·Trang D TrinhMichael J Rybak
Oct 12, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Tanya GurievaMartin C J Bootsma
Nov 15, 2017·Antimicrobial Agents and Chemotherapy·Natalia BlancoUNKNOWN the CDC Epicenters Program
Dec 10, 2017·The Journal of Hospital Infection·B PilmisA Le Monnier
Dec 20, 2017·Current Opinion in Critical Care·Kevan Akrami, Daniel A Sweeney

❮ Previous
Next ❯

Citations

Dec 10, 2019·Current Opinion in Infectious Diseases·Juliette Patrier, Jean-François Timsit
Apr 14, 2020·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Claudia FloresCélia Maria C P A Romão
Mar 20, 2021·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Mirjana Stanić BenićVera Vlahović-Palčevski

❮ Previous
Next ❯

Software Mentioned

Stata

Related Concepts

Related Feeds

Carbapenems (ASM)

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.

Carbapenems

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.