Influence of antibiotics on intestinal tract survival and translocation of environmental Pseudomonas species.

Applied and Environmental Microbiology
S E GeorgeL D Claxton

Abstract

The environmental release of microorganisms has prompted the investigation of potential health effects associated with their release. In this study, survival and translocation to the spleen and liver of several environmental Pseudomonas spp. were investigated in antibiotic-treated mice. Pseudomonas aeruginosa BC16 and P. maltophilia BC6, isolated from a commercial product for polychlorinated biphenyl degradation; P. aeruginosa AC869, a 3,5-dichlorobenzoate degrader; and P. cepacia AC1100, an organism that metabolizes 2,4,5-trichlorophenoxyacetic acid were examined for their survival capabilities in the intestines of mice dosed with clindamycin, kanamycin, rifampin, or spectinomycin. A mouse intestinal isolate, strain PAMG, was included in the study. Following antibiotic pretreatment (1 mg twice daily for 3 days), mice were dosed by gavage with 10(9) CFU of each Pseudomonas strain. At the end of the 5-day test period, strains AC869 and PAMG survived in kanamycin-, rifampin-, spectinomycin-, and clindamycin-treated animals. A statistically significant (P less than 0.05) increase in survival of strain PAMG was observed in clindamycin-, kanamycin-, and spectinomycin-treated mice for the test period. Treatment with clindamycin or ri...Continue Reading

References

Jan 1, 1989·Journal of Toxicology and Environmental Health·S E GeorgeL D Claxton
Jan 1, 1989·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·R van Furth, H F Guiot
Nov 1, 1989·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·S E GeorgeL D Claxton
May 1, 1987·Applied and Environmental Microbiology·M J NelsonP H Pritchard
Oct 1, 1986·The Journal of Antimicrobial Chemotherapy·D van der WaaijG W Welling
Sep 1, 1971·The Journal of Hygiene·D van der Waaij Lekkerkerk Lekkerkerk-v
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May 1, 1981·Journal of Bacteriology·D K ChatterjeeA M Chakrabarty

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Citations

Jul 26, 2012·International Journal of Environmental Research and Public Health·Emmanuel E OdjadjareAnthony I Okoh
Aug 1, 1991·Applied and Environmental Microbiology·S E GeorgeL D Claxton

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