PMID: 6166633Jul 1, 1981Paper

Influence of antigen on immune complex behavior in mice

The Journal of Clinical Investigation
D S FinbloomP H Plotz

Abstract

To explore the possibility that the behavior of immune complexes can, under some circumstances, be directed by the antigen, we have studied the behavior of complexes of identical size made with the glycoproteins, orosomucoid (OR), and ceruloplasmin: or with their desialylated derivatives, asialo-orosomucoid (ASOR) and asialo-ceruloplasmin. Such desialylated proteins are rapidly removed from the circulation by a hepatic cell receptor for galactose, the sugar exposed upon removal of sialic acid. Mixtures of 125I-goat anti-ASOR with either ASOR or OR and mixtures of 125I-rabbit anti-OR with either ASOR or OR form complexes identically. The complexes were separated by density gradient centrifugation and injected intravenously into C3H mice. Blood clearance and hepatic uptake of the OR complexes and ASOR complexes were markedly different. T 1/2 for the goat OR complexes exceeded 300 min, whereas that for the ASOR complexes was 15 min. More detailed studies using rabbit complexes of various sizes revealed that light rabbit complexes behaved similarly to the goat complexes. The light rabbit OR complexes were cleared slowly, with only 18% found in the liver at 60 min, whereas the light rabbit ASOR complexes were cleared much more rapid...Continue Reading

References

Jan 1, 1979·Scandinavian Journal of Immunology·A KijlstraL A van Es
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Citations

Jan 1, 1984·Rheumatology International·L Schrieber, R Penny
Jan 1, 1986·Springer Seminars in Immunopathology·M H Wener, M Mannik
Apr 1, 1982·The Journal of Experimental Medicine·W Emlen, M Mannik
Jan 1, 1982·The Journal of Clinical Investigation·D B CinesH M Friedman
Nov 1, 1987·The Journal of Clinical Investigation·F G Cosio, A P Bakaletz
Jul 16, 2014·Critical Reviews in Biotechnology·Jeong-Hun KangMasaharu Murata
Jan 1, 1994·Journal of Toxicology. Clinical Toxicology·J M Scherrmann
May 1, 1984·Journal of the American Academy of Dermatology·K B Yancey, T J Lawley
Apr 13, 2011·Cancer Science·Masahiro YasunagaYasuhiro Matsumura
Apr 1, 1989·Clinical Immunology and Immunopathology·J C EdbergR P Taylor
Mar 1, 1983·The American Journal of Medicine·R P Kimberly, P Ralph
Jul 1, 1985·Clinical Immunology and Immunopathology·F S JonesR J Kurlander
Jul 1, 2006·Muscle & Nerve·Gordon L WarrenPriscilla M Clarkson
Jul 1, 1982·Arthritis and Rheumatism·M Mannik
Oct 1, 1982·Arthritis and Rheumatism·P H Plotz
Jan 1, 1987·Kidney International·A Rifai

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