PMID: 18199347Jan 18, 2008Paper

Influence of antisperm antibodies in the semen on intracytoplasmic sperm injection outcome

International Braz J Urol : Official Journal of the Brazilian Society of Urology
Sandro C EstevesSidney Verza

Abstract

The aim of this study was to analyze the influence of autoantibodies against spermatozoa present in the semen on the outcome of in vitro fertilization with intracytoplasmic sperm injection (ICSI). We performed a retrospective analysis of clinical and laboratorial data from a six year-period ICSI cycles. Screening for the presence of ASA in the semen, by using the direct immunobeads test (IBT), was available for 351 cycles. According to the percentage of antibody-bound spermatozoa in the semen, we divided the cycles in four groups: I (n = 194): 0%-10% ASA; II (n = 107): 11%-20%; III (n = 33): 21%-50% and IV (n = 17): 51%-100% ASA. Additionally, a group of 349 ICSI cycles performed with ejaculated spermatozoa from oligo/asthenozoospermic men who had insufficient number of motile sperm available for ASA screening was included for comparison. ICSI outcomes were compared among groups and included fertilization rate (2 PN), cleavage rate, cleavage velocity, embryo quality, clinical pregnancy and miscarriage rates. Data were examined statistically, with an alpha level of 5% considered significant. Fertilization, cleavage rate and velocity, percentage of good quality embryos, as well as clinical pregnancy and miscarriage rates did not ...Continue Reading

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Citations

Aug 16, 2011·Clinical Reviews in Allergy & Immunology·Clovis A SilvaEloísa Bonfá
Apr 29, 2014·International Urology and Nephrology·Sandro C EstevesAshok Agarwal
Jan 20, 2016·Asian Journal of Andrology·Ahmad MajzoubAshok Agarwal
Feb 11, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Dong CuiShanhong Yi
Feb 23, 2013·Actas urologicas españolas·B Restrepo, W Cardona-Maya
Nov 30, 2010·Journal of Reproductive Immunology·Armand ZiniSimon Phillips
Oct 14, 2008·Urology·Suren K DasPratap B Singh
Nov 27, 2007·International Journal of Urology : Official Journal of the Japanese Urological Association·Mizuaki SakuraKazunori Kihara
Oct 16, 2016·Journal of Reproductive Immunology·Yumei JiangXiaojing Bai
Nov 8, 2012·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Alaa HamadaAshok Agarwal
Oct 29, 2009·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Sidney VerzaSandro C Esteves
Apr 23, 2011·Obstetrical & Gynecological Survey·Mary Ellen PavoneRalph R Kazer
Feb 23, 2019·International Journal of Molecular Sciences·Mara SimopoulouMichael Koutsilieris
Jul 4, 2018·Nature Reviews. Urology·Sandro C EstevesPeter Humaidan
Nov 7, 2020·Journal of Assisted Reproduction and Genetics·Mounia HaddadGianpiero D Palermo

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