Influence of APOE polymorphism on cognitive and behavioural outcome in moderate and severe traumatic brain injury.

Journal of Neurology, Neurosurgery, and Psychiatry
M ArizaJ Sahuquillo

Abstract

To analyse the influence of apolipoprotein (APOE) epsilon4 status on the cognitive and behavioural functions usually impaired after moderate and severe traumatic brain injury (TBI). In all, 77 patients with TBI selected from 140 consecutive admissions were genotyped for APOE. Each patient was subjected to neuropsychological and neurobehavioural assessment at least 6 months after injury. Performance of participants carrying the epsilon4 allele was notably worse on verbal memory (Auditory Verbal Learning Test), motor speed, fine motor coordination, visual scanning, attention and mental flexibility (Grooved Pegboard, Symbol Digit Modalities Test and part B of the Trail Making Test) and showed considerably more neurobehavioural disturbances (Neurobehavioral Rating Scale-Revised) than the group without the epsilon4 allele. In particular, performance on neuropsychological tasks that are presumed to be related to temporal lobe, frontal lobe and white matter integrity is worse in patients with the APOE epsilon4 allele than in those without it. More neurobehavioural disturbances are observed in APOE epsilon4 carriers than in APOE epsilon2 and epsilon3 carriers.

References

May 11, 1991·Lancet·P R WenhamG Blandell
Feb 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M J IgnatiusE M Shooter
Dec 12, 2000·Learning & Memory·D F Tate, E D Bigler
Oct 19, 2001·Journal of Neurology, Neurosurgery, and Psychiatry·S R McCauleyG L Clifton
Jun 18, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·S FlemingerA Giora
Jul 24, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·K MillarG M Teasdale
Oct 22, 2004·Brain : a Journal of Neurology·Laury ChamelianAnthony Feinstein
Jul 22, 2005·Brain : a Journal of Neurology·G M TeasdaleJ A R Nicoll

❮ Previous
Next ❯

Citations

Feb 10, 2009·Applied Psychophysiology and Biofeedback·Kirtley E Thornton, Dennis P Carmody
Dec 3, 2011·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Khalid A Hanafy, Magdy H Selim
Jul 25, 2009·Antioxidants & Redox Signaling·Rao Muralikrishna Adibhatla, James Franklin Hatcher
Apr 1, 2008·Journal of Neurotrauma·Weidong ZhouKeith A Crutcher
Aug 4, 2009·Journal of Neurotrauma·Lisa M MoranKeith O Yeates
Feb 24, 2012·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Andrew J PetkusElizabeth Barrett-Connor
Feb 25, 2011·Alzheimer Disease and Associated Disorders·Emily Joy RogalskiMarek-Marsel Mesulam
Oct 1, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A JawaidP E Schulz
Jun 24, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·H Houlden, R Greenwood
Feb 9, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·S Duke HanMark W Bondi
Jun 15, 2007·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Chandra A ReynoldsNancy L Pedersen
Jan 2, 2010·Neurosurgical Focus·Efthimios DardiotisGeorgios M Hadjigeorgiou
Jan 8, 2008·Future Lipidology·Rao Muralikrishna Adibhatla, J F Hatcher
Aug 11, 2012·Brain Imaging and Behavior·Starla M WeaverJordan Grafman
May 4, 2011·Brain Injury : [BI]·Rahida Mohd ShadliFaridah Abdul Rashid
Jun 19, 2009·Journal of Neuropathology and Experimental Neurology·Ann C McKeeRobert A Stern
Jul 8, 2011·PM & R : the Journal of Injury, Function, and Rehabilitation·Yvette P Conley, Sheila Alexander
Oct 21, 2015·Journal of the International Neuropsychological Society : JINS·Victoria C Merritt, Peter A Arnett
Mar 27, 2013·Critical Care Medicine·Robert D Stevens, Raoul Sutter
Jan 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·Federica AgostaMaria Luisa Gorno-Tempini
Apr 24, 2015·Journal of Neurology, Neurosurgery, and Psychiatry·Irfahan KassamMichael D Cusimano
Mar 15, 2013·Neurological Research·Nelli LakisLawrence S Chin
Jun 14, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Michael W WeinerUNKNOWN Department of Defense Alzheimer's Disease Neuroimaging Initiative
May 19, 2016·Journal of Clinical and Experimental Neuropsychology·Victoria C MerrittPeter A Arnett
May 3, 2012·Brain Imaging and Behavior·Sara B Rosenbaum, Michael L Lipton
Dec 7, 2018·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Victoria C MerrittLisa Delano-Wood
Feb 6, 2017·Neurology·Walter F StewartMichael L Lipton
Oct 6, 2017·Neurology·Michael W WeinerDallas P Veitch
Sep 18, 2017·British Journal of Sports Medicine·Thomas Roland TerrellLeslie Galloway

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.