PMID: 9183304May 1, 1997Paper

Influence of apolipoprotein A-1 promoter polymorphism on lipid levels and responses to dietary change in Finnish adults

Journal of Internal Medicine
Q H MengM J Tikkanen

Abstract

To analyse the association between the G/A polymorphism in the apolipoprotein A-1 (apo A-1) promoter region and plasma lipid levels, as well as their responses to dietary change, in Finnish adults. Blood samples from 86 subjects (42 men. 44 women) who attended a dietary intervention study carried out in North Karelia in 1993 were available for the current analysis. The diet study consisted of a 2-week baseline period, followed by an 8-week intervention period, and an 8-week switchback period. Diet was modified to a low-fat, low-cholesterol diet during the dietary intervention. Fasting plasma lipid, lipoprotein and apoliprotein levels were determined. At baseline, the high-density lipoprotein (HDL) cholesterol and apo A-1 levels were higher (P < 0.01) and the triglyceride levels were lower (P < 0.05) in men, but not in women, with the A allele. The differences in HDL cholesterol and apo A-1 levels between genotypes remained during the lowfat, low-cholesterol diet and switchback periods. Apart from the difference between responses in apo A-1 during switchback to the original diet, lipid responses to dietary change did not differ significantly between genotypes. Our findings indicate a significant association between the apo A-1 p...Continue Reading

Citations

Dec 21, 2000·Current Atherosclerosis Reports·J M Ordovas, E J Schaefer
Jun 29, 2005·International Journal of Cardiology·Yan Qing MaBrian Tomlinson
May 27, 1999·The Proceedings of the Nutrition Society·J M Ordovas
Aug 9, 2007·Lipids in Health and Disease·Ali I AlbahraniSaid Al-yahyaee
Mar 18, 2010·The Journal of Nutritional Biochemistry·Valerio CostaAlfredo Ciccodicola
Mar 30, 1999·Current Opinion in Lipidology·J M Ordovas, E J Schaefer
Apr 30, 2003·The American Journal of Clinical Nutrition·Lindsey F MassonAlison Avenell
Feb 14, 2006·The American Journal of Clinical Nutrition·José M Ordovas

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