PMID: 6972977Jan 1, 1981Paper

Influence of Ara-C on effector activity of cytotoxic T-lymphocytes in vitro

Journal of Immunopharmacology
G MiglioratiE Bonmassar

Abstract

Mouse T-lymphocytes carrying the H-2d haplotype were sensitized in vitro against allogeneic spleen cells homozygous for the H-2b haplotype. Cytolytic T-lymphocytes (CTL) were tested in a 4 hr cytotoxicity assay against 51Cr-labeled H-2b RBL-5 lymphoma cells. The cytotoxic activity of CTL was markedly increased by preincubation with Ara-C (1 through 1000 micrograms/ml, 1 hr at 37 degrees C). Limited but significant increase of cytotoxicity occurred when the drug was added to the effector-target mixture, or when target cells were preincubated with Ara-C using the same conditions adopted for the in vitro treatment of CTL. It is suggested that the present findings would contribute to elucidate the mechanism underlying antitumor synergistic effects between host's responses and treatment with antineoplastic agents.

References

Jun 30, 1975·Annals of the New York Academy of Sciences·G WeissmannP K Tsung
Sep 1, 1977·The Journal of Experimental Medicine·H R MacDonald, C J Koch
Jan 1, 1977·Contemporary Topics in Immunobiology·P Golstein, E T Smith
Jan 1, 1973·Transplantation Reviews·C S Henney
Oct 1, 1974·Journal of the National Cancer Institute·R B HerbermanK S Chang
Jan 1, 1974·Advances in Immunology·J C Cerottini, K T Brunner
Jan 1, 1980·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C RiccardiA Goldin

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Citations

Jan 1, 1984·International Journal of Immunopharmacology·G MiglioratiC Riccardi
Oct 1, 1996·Critical Reviews in Food Science and Nutrition·V RaviC Balagopalan
Oct 22, 2014·Skeletal Radiology·Anirban SensarmaBehrang Amini

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