PMID: 25796153Mar 23, 2015Paper

Influence of Artemisia annua extract derivatives on proliferation, apoptosis and metastasis of osteosarcoma cells.

Pakistan Journal of Pharmaceutical Sciences
Chao TangDapeng Shi

Abstract

Regarding the Artemisia annua extract derivatives called dihydroarteminin (DHA) as the object, we studied about its influence to the proliferation, apoptosis and metastasis of human osteosarcoma cells. First, we cultured in vitro the osteosarcoma cell strain and divided them into groups, then detected the cell proliferation, apoptosis and cell metastasis, etc by multiple measurement technique. Finally, we observed the influence of DHA to human osteosarcoma cells. Osteosarcoma cells were all sensitive to DHA, and the appropriate concentration range was 10~40μM. DHA could effectively restrain its protein expression, and there was a significant difference between experimental group and control group. These finding suggest that, the Artemisia annua extract derivatives (DHA) has a biological effect of observably restraining the proliferation and metastasis of human osteosarcoma cells and promoting the tumour cell apoptosis.

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

The Japanese journal of experimental medicine
M SekiguchiE Ishikawa
M. S. C. Veterinarian
J B DAVIDSON
Zhong yao tong bao = Bulletin of Chinese materia medica
Y Y Tu
International Journal of Clinical Pharmacology and Therapeutics
Yong DingHuan Ding
© 2021 Meta ULC. All rights reserved