Influence of asafoetida on prevention and treatment of memory impairment induced by d-galactose and NaNO2 in mice

American Journal of Alzheimer's Disease and Other Dementias
Seyyed Majid Bagheri, Mohammad Hossein Dashti-R

Abstract

In Iranian traditional medicine, asafoetida is introduced as a valuable remedy for nervous disorders. Dementia was induced by injection of d-galactose and NaNO2 for 60 consecutive days. Animals were divided into normal control (NC), dementia control (DC), dementia prophylactic (DP), and dementia treated (DT). The learning and memory functions were examined by 1-way active and passive avoidance tests, using a shuttle box device. Avoidance response in training tests and 1 and 3 weeks later was significantly increased in NC, DP, and DT groups compared to the DC group. Step through latency in all groups was significantly greater than the DC group. Total time spent in light room, which shows the memory retention ability, in DP, NC, and DT was significantly greater than the DC group. Our findings indicate that asafoetida could prevent and treat amnesia. These beneficial effects maybe related to some constituent's effectiveness such as ferulic acid and umbelliferone.

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Citations

Jun 28, 2016·International Journal of Food Sciences and Nutrition·Honggai YangWenyuan Gao
Oct 3, 2015·Journal of Evidence-based Complementary & Alternative Medicine·Seyyed Majid BagheriMohammad Hossein Dashti-R
May 6, 2020·Mini Reviews in Medicinal Chemistry·Mohammad SabzehzariAmirhossein Sahebkar
Apr 22, 2021·CNS & Neurological Disorders Drug Targets·Himanshi Varshney, Yasir Hasan Siddique

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