PMID: 9418950Jan 7, 1998Paper

Influence of atenolol and/or metformin on glutathione and magnesium levels in diabetic rats

Journal of Applied Toxicology : JAT
S A Ewis, M S Abdel-Rahman

Abstract

Recently there has been growing interest in studying the differences between different classes of antihypertensive drugs in preventing cardiovascular events in diabetic patients. Hypomagnesemia is common in diabetes mellitus, and correlates to its chronic complications and the associated alteration of the antioxidant enzyme activity. Depletion of reduced glutathione (GSH) in the blood has been demonstrated with myocardial injuries associating hypomagnesemia. A previous study has demonstrated a beneficial effect of metformin hydrochloride (Met), an antihyperglycemic drug, on both magnesium (Mg) and GSH levels in diabetic animals. The purpose of this study was to investigate the effect of oral atenolol, metformin (50 and 60 mg kg[-1] day[-1], respectively) and their combination for 14 days on Mg and GSH levels in blood, liver and heart of diabetic male Wistar rats, as these two parameters have been shown to be altered in diabetics and linked to myocardial ischemic injuries. The results of this investigation showed a state of low levels of Mg and GSH in both blood and liver of the diabetic animals. Treatment with atenolol alone did not change these levels significantly, however administration of metformin or atenolol/metformin inc...Continue Reading

Citations

Jan 29, 2003·The Journal of Nutritional Biochemistry·Delcy V. Rodriguez de Sotillo, M Hadley
Jul 27, 2001·Diabetes Technology & Therapeutics·N F Wiernsperger
Jan 5, 2002·Journal of Basic and Clinical Physiology and Pharmacology·S OzyazganA G Akkan
Dec 1, 1994·Community Dentistry and Oral Epidemiology·V L Searcy, M C Chisick
Dec 1, 1970·The International Journal of the Addictions·D M Casto
Sep 23, 2003·Diabetes & Metabolism·X M LeverveN F Wiernsperger
Jan 23, 2004·Journal of Pharmacological Sciences·Michel K T PoonKam-Ming Ko
Jun 3, 2016·Pharmaceutical Biology·Seyed Soheil Saeedi SaraviAhmad Reza Dehpour
May 20, 2005·Human & Experimental Toxicology·R YanardagO Karabulut-Bulan
Feb 12, 2019·Scientific Reports·Steef KurstjensJeroen H F de Baaij
Jul 26, 2019·BioFactors·Alena PecinováTomáš Mráček
Feb 6, 2020·Canadian Journal of Physiology and Pharmacology·Hacene BourasJoost G J Hoenderop

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