PMID: 22580538May 15, 2012Paper

Influence of atorvastatin on serum amyloid A-low density lipoprotein complex in hypercholesterolemic patients

Pharmacological Reports : PR
Kazuhiko KotaniAlejandro Gugliucci

Abstract

The complex of serum amyloid A(SAA) and low-density lipoprotein (LDL), SAA-LDL, is considered a new and unique marker of oxidatively-modified LDL particles, which is associated with atherosclerotic conditions. This study investigated the influence of atorvastatin treatment on circulating SAA-LDL levels among asymptomatic hypercholesterolemic patients. A total of 26 patients (mean age 63 years) received 10 mg/daily atorvastatin during a 12-week treatment period. The levels of LDL cholesterol and SAA-LDL, but not high-sensitivity C-reactive protein and SAA, were significantly reduced after the treatment. Stepwise adjusted regression analyses revealed that changes of SAA-LDL were significantly and positively correlated with those of SAA, while absolute changes were small, which warrants further investigation. The results suggest that atorvastatin may beneficially reduce SAA-LDL, and SAA-LDL may be a sensitive measure for monitoring the efficacy and antioxidant functions of atorvastatin.

Associated Clinical Trials

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Citations

Oct 23, 2012·Pharmacological Reports : PR·Hong-Bo XiaoDa-Sheng Zhang
Oct 19, 2016·International Journal of Cardiology·Yusuke MiyazakiTatsuya Morimoto
Mar 12, 2015·The Cochrane Database of Systematic Reviews·Stephen P AdamsJames M Wright
Jul 7, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Patricia G WilsonLisa R Tannock

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