Influence of atypical features on the quality of prophylactic effectiveness of long-term lithium treatment in bipolar disorders

Bipolar Disorders
Andrea PfennigAnne Berghöfer

Abstract

There is still debate about whether the quality of long-term efficacy of lithium in patients with bipolar disorders is influenced by atypical features. Extended Cox regression models allow for the use of all follow-up data on diseases with multiple episodes. The aim of the present analysis was to apply the best suited of these models to analyze the influence of atypical features on the widely used outcome measure of time to recurrence in a large multicenter cohort of lithium responders established by the International Group for the Study of Lithium Treated Patients. A conditional extended Cox model with a random frailty term was applied to the data of 336 bipolar I and II disorder patients, all of whom were responders to lithium with treatment for up to 30 years. Differences were found in the long-term outcome, even in patients who have demonstrated a relatively good response to lithium treatment. The hazard for recurrence was negatively influenced by the presence of atypical features, mainly mood-incongruent psychotic symptoms, interepisodic residual symptomatology, and rapid cycling. As a result of the findings, physicians should regularly reassess the quality of response in bipolar disorder patients with atypical features an...Continue Reading

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Citations

Oct 25, 2012·Translational Psychiatry·F S GoesJ B Potash
Jun 21, 2015·International Journal of Bipolar Disorders·Pierre Alexis GeoffroyFrank Bellivier
Jan 1, 2013·International Journal of Bipolar Disorders·Anne BerghöferAndrea Pfennig
Apr 25, 2012·Bipolar Disorders·Michael Gitlin, Mark A Frye
Jun 20, 2016·Journal of Affective Disorders·Pierre Alexis GeoffroyFrank Bellivier
Apr 14, 2017·The Australian and New Zealand Journal of Psychiatry·Olga Zivanovic
Jul 12, 2014·The British Journal of Psychiatry : the Journal of Mental Science·Lars Vedel KessingPer Kragh Andersen
Mar 3, 2020·The American Journal of Psychiatry·Rita SuriMichael Gitlin
Jul 6, 2012·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Cynthia Calkin, Martin Alda
Aug 26, 2016·The Australian and New Zealand Journal of Psychiatry·Sarah SporticheFrank Bellivier
Jan 2, 2021·The American Journal of Psychiatry·Rita SuriMichael Gitlin

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Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.