Influence of baicalin on the expression of receptor activator of nuclear factor-kappaB ligand in cultured human periodontal ligament cells

Pharmacology
Guo-fang WangFa-Ming Chen

Abstract

Baicalin is a flavonoid purified from the medicinal plant Scutellaria baicalensis Georgi. It has been reported that baicalin exhibits antibacterial, anti-inflammatory and analgesic effects and can inhibit nuclear factor-kappaB activation. Periodontal disease is a chronic infective disease of the periodontium caused by bacteria present in dental plaque inducing alveolar bone resorption until teeth are lost. Human periodontal ligament (HPDL) is the connective tissue between alveolar bone and tooth. Receptor activator of nuclear factor-kappaB ligand (RANKL), a member of the tumor necrosis factor (TNF) ligand family, plays an important role in osteoclastogenesis from osteoclast precursors to mature osteoclasts. In this study we investigate the effects of baicalin on RANKL protein production and messenger RNA (mRNA) expression induced by IL-1beta in cultured HPDL cells. To induce RANKL expression, IL-1beta was added to serum-free medium HPDL cells and incubated. Various concentrations of baicalin (0, 0.001, 0.01 and 0.1 microg/ml) were added to the medium and the cells were treated for 0, 12, 24, 48 and 72 h, respectively. RANKL in the cells was detected using immunocytochemistry. The mRNA of RANKL, osteoprotegerin (OPG) and cycloox...Continue Reading

References

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Citations

Mar 25, 2011·Critical Reviews in Food Science and Nutrition·R GonzálezF Sánchez de Medina
Feb 25, 2014·Pharmacology, Biochemistry, and Behavior·Dhirendra Pratap Singh, Kanwaljit Chopra
Jan 31, 2014·Journal of Periodontology·Zhenhua PeiLi Mei
Jan 31, 2008·Journal of Periodontal Research·X CaiZ Cao
Mar 31, 2019·Dentistry Journal·Mesfin YimamQi Jia
May 3, 2019·The Journal of Nutritional Biochemistry·Lijuan ZhangHongwei Si

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