PMID: 9174245May 20, 1997Paper

Influence of BDNF on the expression of the dopaminergic phenotype of tissue used for brain transplants

Brain Research. Developmental Brain Research
J ZhouG M Stern

Abstract

Brain-derived neurotrophic factor (BDNF) has previously been shown by this laboratory among others to promote survival and differentiation of central dopaminergic neurons and to stimulate expression of the dopaminergic phenotype in fetal cerebrocortex in vitro. We have examined the effect of BDNF antibody on nigral dopaminergic neurons in vivo and in vitro. It reduced the survival of rat fetal dopaminergic neurons in culture (up to 40% died). The BDNF antibody also caused ipsilateral rotation after a single in vivo intranigral injection in the adult rats. Pre-treatment of fetal nigral neurons with BDNF improved the performance of dopaminergic cells in fetal nigral transplants based on surviving TH+ cells numbers. Thus, parkinsonian rats receiving fetal nigral cells treated with BDNF showed a significantly greater reduction of turning over the 3 weeks following transplantation, compared with the rats receiving untreated nigral transplants. However, the average number of tyrosine hydroxylase (TH)-positive neurons in the grafts of rats receiving fetal nigral cells treated with BDNF was 211 +/- 35 which was only about 20% of the cell number (1012 +/- 223, mean +/- S.E.M.) found in those receiving untreated nigral transplants. These...Continue Reading

References

Apr 1, 1993·Nature·A Björklund
Dec 23, 1996·Brain Research. Developmental Brain Research·J ZhouG M Stern
Jul 1, 1991·The European Journal of Neuroscience·Wilma J. FriedmanHåkan Persson
Feb 1, 1946·The Anatomical Record·M ABERCROMBIE

❮ Previous
Next ❯

Citations

May 13, 1999·Brain Research. Developmental Brain Research·F B Pliego RiveroH F Bradford
Sep 18, 1998·Neuroscience Letters·J ZhouE R Jauniaux
Dec 7, 2013·Neuropathology and Applied Neurobiology·G Cisbani, F Cicchetti
Apr 20, 2016·Frontiers in Cellular Neuroscience·Stefanie SeilerHans Rudolf Widmer
Sep 29, 1999·The Journal of Comparative Neurology·M A Alonso-VanegasA F Sadikot
Mar 17, 2020·Journal of Neural Transmission·John D Elsworth

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.