Influence of beta-adrenoceptor blocking agents on the turnover rate of cardiac and splenic noradrenaline in rats

British Journal of Pharmacology
J M Alexandre, C Chevillard

Abstract

1 The effects of (+) and (+/-)-propranolol, pindolol, alprenolol, practolol, acebutolol and bretylium were studied on the turnover rate of noradrenaline in heart and spleen of rats. 2 Bretylium (8 mg/kg) greatly reduced the turnover rate of noradrenaline in both organs. 3 (+)-Propranolol (4 and 10 mg/kg) also diminished the turnover rate of noradrenaline, but its effects were smaller than those of (+/-)-propranolol (4 and 10 mg/kg). 4 Pindolol (300 micrograms/kg) greatly increased the turnover rate of noradrenaline; this effect was especially important in the spleen. 5 Alprenolol (4 and 10 mg/kg) acebutolol (20 and 40 mg/kg) practolol (10 mg/kg) did not produce any significant change. 6 These effects are compatible with the view that beta-adrenoceptor blocking agents may affect noradrenaline release in different manners: anaesthetic properties of some of these drugs and blockade of beta 2 prejunctional adrenoceptors produce a diminished release of transmitter, whereas the intrinsic sympathomimetic action of pindolol causes the opposite effect.

References

Mar 1, 1976·Acta Physiologica Scandinavica·L Stjärne, J Brundin
Mar 1, 1976·The Journal of Pharmacy and Pharmacology·I E Hughes, B Kneen
Apr 1, 1975·British Journal of Pharmacology·P M Dawes, D C Faulkner
Mar 1, 1973·The Journal of Pharmacy and Pharmacology·E J Mylecharane, C Raper
Jun 19, 1973·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·J WagnerH J Schümann
Jun 1, 1973·British Journal of Pharmacology·B BasilD R Maxwell
Jan 1, 1974·Naunyn-Schmiedeberg's Archives of Pharmacology·K H RahnG Planz
Jan 1, 1968·British Journal of Pharmacology and Chemotherapy·D Dunlop, R G Shanks
Dec 1, 1968·The Journal of Pharmacy and Pharmacology·M D DayP R Warren
Aug 1, 1970·The Journal of Pharmacy and Pharmacology·B AbladB Waldeck
Nov 1, 1970·The Journal of Pharmacy and Pharmacology·A M Barrett, B Nunn
Oct 1, 1964·British Journal of Pharmacology and Chemotherapy·B G BENFEY, D R VARMA
Apr 1, 1965·British Journal of Pharmacology and Chemotherapy·A MORALES AGUILERA, E M VAUGHANWILLIAMS

Citations

Feb 1, 1987·Toxicology·A SkoczyńskaF J Bĕhal

Related Concepts

Adrenergic beta-Antagonists
Metazoa
Heart
Myocardium
Norepinephrine, (+, -)-Isomer
Spleen
Rats, Laboratory
In Vitro [Publication Type]

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