Influence of bilateral oophorectomy upon lipid metabolism

Maturitas
Y SudaS Nozawa

Abstract

Reduction in serum level of estrogen has been thought to result in hyperlipidemia which triggers atherosclerosis, and even to lead to cardiovascular diseases, in postmenopausal women. The present study was designed to investigate the influence of bilateral oophorectomy (OPX), which induces as much reduction in serum estrogen level as menopause, upon lipid metabolism, especially the serum levels of total cholesterol. In 31 OPX subjects and 31 age- and body size-matched premenopausal controls, the serum levels of total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein (VLDL-C), apoprotein-A1 (Apo-A1), apoprotein-B (Apo-B), lipoprotein lipase (LPL) and lipoprotein-a [LP(a)] were measured as indices of lipid metabolism and the index of arteriosclerosis was calculated. TC level was significantly higher in the OPX group than in the premenopausal control group, being 8995 +/- 244 (mean +/- S.E.) mmol/l and 7757 +/- 228 mmol/l, respectively. LDL-C and Apo-B levels and the index of arteriosclerosis were all significantly higher in the OPX group than in the premenopausal control groups. However, there were no significant intergroup ...Continue Reading

References

Jan 1, 1971·Annals of Internal Medicine·W B KannelP M McNamara
Jun 1, 1994·The American Journal of Cardiology·C D FurbergM A Espeland
Jul 17, 2004·Journal of Atherosclerosis and Thrombosis·Takao MaruyamaUNKNOWN Research Committee on Primary Hyperlipidemia of the Ministry of Health and Welfare of Japan

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Citations

Oct 8, 2003·Gynecologic Oncology·Francesmary Modugno, UNKNOWN Ovarian Cancer and High-Risk Women Symposium Presenters
May 4, 2007·Menopause : the Journal of the North American Menopause Society·Donna ShoupeJonathan S Berek
Jul 13, 2002·Clinical Chemistry and Laboratory Medicine : CCLM·Lúcia C N ErberichMarileia Scartezini
Jun 5, 2010·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Volkan TunaTekirdag Ali Ismet
Oct 28, 2004·American Journal of Obstetrics and Gynecology·Sean C DowdyLynn C Hartmann

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