Influence of bile on kinetic behavior of colonic epithelial cells of the rat

Digestion
E E Deschner, R F Raicht

Abstract

The acute effect of bile deprivation on colonic epithelial cell proliferation in Sprague-Dawley rats was investigated and compared with its effect on jejunum and ileum. 2. days after the creation of bile fistula, tritiated thymidine was injected and animals sacrificed 1 and 24 h later. Compared with control untreated animals, sham-operated restrained rats had a reduced labeling and mitotic index of the colonic epithelial cell population as well as a slower migration of cells to the lumen. Colonic cell proliferation in animals deprived of bile flow was reduced a further 50%. Moreover, no evidence of cell migration or appreciable decline in grain density was seen over 24 h in bile fistula rats. Alterations in cell proliferation in both sham and bile fistula treated rats became less marked as one proceeded proximally to the small bowel. Therefore, significant alterations in cell kinetics result when normal bile flow is interrupted, suggesting its importance in the regulatory control of colonic cell proliferation.

Citations

Jan 1, 1996·Surgery Today·A TocchiS Tagliacozzo
Nov 1, 1993·Digestive Diseases and Sciences·M ChuK Borch
Feb 4, 1985·Klinische Wochenschrift·N Breuer, H Goebell
Jan 1, 1984·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·H WeitzM Eder
Feb 12, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Qingchao ZhuHuanlong Qin
Nov 1, 1985·Computer Methods and Programs in Biomedicine·H P Meinzer, B Sandblad
Jan 1, 1990·Journal of Gastroenterology and Hepatology·A W Burgess, A M Sizeland
Apr 23, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Betsy C WertheimPatricia A Thompson
Nov 1, 1984·The Journal of Clinical Investigation·F R DeRubertisR Saito
Jan 1, 1983·Nutrition and Cancer·D M KlurfeldD Kritchevsky
Jan 1, 1993·Scandinavian Journal of Gastroenterology. Supplement·I P Van Munster, F M Nagengast
Mar 1, 1988·American Journal of Surgery·C M TownsendJ C Thompson
Aug 1, 1990·The British Journal of Surgery·A D SpigelmanR K Phillips
Mar 1, 1991·The British Journal of Surgery·A D SpigelmanR K Phillips
Dec 1, 1984·Cancer·M W MulhollandJ P Delaney
Dec 1, 1988·Cancer·L RoncucciN J Chahin
Nov 1, 1986·Cell and Tissue Kinetics·H P Meinzer, B Sandblad

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