PMID: 517649Dec 1, 1979Paper

Influence of bile salts on hepatic transport of dibromosulphthalein

The American Journal of Physiology
R J VonkD K Meijer

Abstract

The influence of bile salts on hepatic transport of the organic anion dibromosulphthalein (DBSP) was investigated in rats. Bile salts influence the hepatic uptake, intracellular binding, and biliary excretion of DBSP. The overall effect depends on the administered dose of bile salts and DBSP. High doses of bile salts inhibited hepatic uptake of DBSP, whereas low doses of bile salts stimulated bile flow and simultaneously increased maximal biliary excretion of DBSP. The uncharged nonbile salt choleretic ouabain also stimulated biliary DBSP excretion. In contrast, the anionic nonbile salt choleretics, ethacrynic acid and theophylline, did not stimulate biliary excretion of DBSP. Because DBSP inhibited biliary excretion of ethacrynic acid and its metabolites, the lack of a stimulatory effect of ethacrynic acid choleresis might be explained by concomitant inhibition of biliary excretion of DBSP, masking the stimulatory effect of ethacrynic acid. Biliary transport maximum of DBSP was highly correlated with bile flow. The biliary clearance (Vmax/Km) was only moderately changed by bile salt administration, whereas the increase in the maximal biliary excretion rate was more pronounced, implying that the apparent Km for biliary excretio...Continue Reading

References

Dec 23, 1976·The New England Journal of Medicine·N B Javitt
Dec 1, 1976·The American Journal of Physiology·Y DelageS Erlinger
Aug 1, 1975·Australian Journal of Biological Sciences·A G Clark, K M Rogers
Apr 1, 1976·The American Journal of Physiology·J Graf, M Peterlik
Feb 1, 1971·The Journal of Pharmacy and Pharmacology·A G ClarkR L Smith
Jul 1, 1973·The American Journal of Physiology·R Clarenburg, C C Kao
Jan 1, 1974·Investigative Radiology·R N BerkP M Loeb
Jul 1, 1974·The American Journal of Physiology·J L Barnhart, B Combes
Dec 1, 1970·The American Journal of Physiology·E L Forker
Oct 1, 1964·Proceedings of the Society for Experimental Biology and Medicine·N B JAVITT

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