PMID: 41563Nov 1, 1979

Influence of biogenic amines on the growth of xenografted human colorectal carcinomas

British Journal of Cancer
P J Tutton, G G Steel

Abstract

The influence of some biogenic amines and amine-receptor-blocking drugs in the growth rate of human colorectal carcinomas propagated as s.c. xenografts in immune-deprived mice was studied. In mice treated with adrenaline, a beta-adrenergic agonist, the growth of xenografts was suppressed for 2 days, after which growth was resumed at a rate similar to that in control animals. Treatment with the phosphodiesterase inhibitor theophylline prolonged the adrenaline-induced inhibition of growth. Treatment with the beta-adrenergic antagonist sotalol or practolol increased the rate of tumour growth. Treatment with either serotonin or the histamine H2-receptor agonist Dimiprit had no effect on tumour growth rate. However, the antiserotoninergic drug BW 501C and the histamine H2-receptor antagonist cimetidine each caused short-term suppression of tumour growth.

References

May 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Justin StebbingMark Bower
Jun 28, 2012·European Journal of Gastroenterology & Hepatology·Hyun-Ki LeeSang Min Park
Aug 14, 1982·British Medical Journal·A L Harris, I E Smith
Jun 1, 1996·Clinical and Experimental Pharmacology & Physiology·P F SheehanD H Barkla
Mar 17, 2010·International Journal of Cancer. Journal International Du Cancer·Jessica ChubakMargaret T Mandelson
Jan 1, 1987·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·P J Tutton, D H Barkla
May 18, 1999·International Journal of Cancer. Journal International Du Cancer·A R SassonR M Hoffman
Feb 14, 2006·BJU International·Emad J SiddiquiCecil S Thompson

Related Concepts

Histamine Measurement
Mice, Inbred CBA
Phosphodiesterase Inhibitors
Amines
Practolol
Serotonin Measurement
Serotonin
Antagonist Muscle Action
Neoplasms
Neoplasm Transplantation

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