Influence of body load on the gait pattern in Parkinson's disease

Movement Disorders : Official Journal of the Movement Disorder Society
Volker Dietz, G Colombo

Abstract

The influence of body unloading (to 75, 50, and 25% body weight) on lower leg muscle activation during treadmill walking was investigated in patients with Parkinson's disease, age-matched and young healthy subjects. The aim of the study was to test the hypothesis that patients suffer from impaired extensor load receptor function. Although lower leg flexor muscle electromyographic (EMG) activity was relatively independent of body load, lower leg extensor EMG activity was markedly load sensitive. The EMG amplitude of the latter decreased with body unloading during stepping in all three groups of subjects. The load sensitivity progressively increased from patients to age-matched to young healthy subjects. In addition, the absolute level of leg extensor EMG amplitude during the stance phase of stepping became progressively larger from patients to age-matched subjects to young healthy subjects. It is suggested that decreased sensitivity of extensor load reflex mechanisms contributes to impaired gait in elderly subjects and is more pronounced in parkinsonian patients.

References

Jan 1, 1992·Experimental Brain Research·V DietzM Trippel
Jul 1, 1991·Annals of Neurology·P J DelwaideA Maertens de Noordhout
Nov 1, 1988·Electroencephalography and Clinical Neurophysiology·G A HorstmannV Dietz
Dec 4, 1989·Neuroscience Letters·V DietzA Gollhofer
May 1, 1967·Neurology·M M Hoehn, M D Yahr
May 1, 1995·Annals of Neurology·V DietzL Baumgartner
Aug 1, 1994·Journal of Neurophysiology·F B Horak, H C Diener
Jan 1, 1994·Experimental Brain Research·J P GossardH Hultborn
Dec 1, 1995·Electroencephalography and Clinical Neurophysiology·V DietzW Berger

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Citations

Jun 6, 2008·Experimental Brain Research·Margaret K Y MakChristina Hui-Chan
Dec 29, 2000·Experimental Brain Research·C M BastiaanseV Dietz
Jun 2, 2007·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Bridget R KellerSasha N Zill
Nov 23, 2006·Biological cybernetics·Alain Frigon, Serge Rossignol
Apr 28, 2004·Clinical Biomechanics·Vincent K RamseyMike Horvat
Oct 20, 2004·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·Ing-Shiou HwangChun-Hou Wang
Jul 31, 2003·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·V Dietz
Aug 31, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Serge Rossignol
Apr 1, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·M VaugoyeauJ Massion
Oct 22, 2008·Brain : a Journal of Neurology·V Dietz, J Michel
Jul 19, 2000·Gait & Posture·V Dietz, J Duysens
Jan 27, 2006·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·S C WearingA P Hills
Mar 25, 2014·Journal of Neurology·Senja H G MensinkLars B Oude Nijhuis
Jun 8, 2012·Parkinsonism & Related Disorders·Alessandro PicelliNicola Smania
Jan 31, 2017·The International Journal of Neuroscience·Anna FurnariRoberto Casale
Apr 6, 2017·Journal of Neuroengineering and Rehabilitation·L AwaiM Bolliger
Nov 4, 2004·Canadian Journal of Physiology and Pharmacology·J Maxwell Donelan, Keir G Pearson
Dec 16, 2016·Journal of Neurologic Physical Therapy : JNPT·Miriam R RaffertyDaniel M Corcos
Jul 3, 2018·Rejuvenation Research·Olalla BelloMiguel Fernandez-Del-Olmo
Oct 8, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Hubertus J A van HedelVolker Dietz
May 9, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Olalla BelloMiguel Fernandez-del-Olmo
Jun 22, 2018·Journal of Neuroengineering and Rehabilitation·Salil ApteHeike Vallery
Aug 18, 2018·International Journal of Rehabilitation Research. Internationale Zeitschrift Für Rehabilitationsforschung. Revue Internationale De Recherches De Réadaptation·Mohammad AlwardatAntonio Pisani
Nov 9, 2018·Frontiers in Physiology·Gian Mario MigliaccioJohnny Padulo
Feb 4, 2010·The International Journal of Eating Disorders·Tyson A OberndorferScott C Matthews
Oct 3, 2002·Nature Reviews. Neuroscience·Volker Dietz
Apr 1, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ursula F BailerWalter H Kaye
Dec 24, 2005·Physiological Reviews·Serge RossignolJean-Pierre Gossard
Jun 2, 2015·Nature Communications·Bradley AkitakeCraig Montell
Sep 30, 2008·Somatosensory & Motor Research·Michael J FalvoGammon M Earhart
Jul 15, 2015·International Journal of Rehabilitation Research. Internationale Zeitschrift Für Rehabilitationsforschung. Revue Internationale De Recherches De Réadaptation·Fabrizio StocchiManuela Galli
Dec 6, 2018·Sensors·Martín MartínezMaría A Pastor
Feb 23, 2020·Scientific Reports·Luisa RoederGraham K Kerr
Mar 9, 2021·Archives of Physical Medicine and Rehabilitation·Patricia Lorenzo-GarcíaCelia Álvarez-Bueno

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