Influence of body mass index in anti-Müllerian hormone levels in 951 non-polycystic ovarian syndrome women followed at a reproductive medicine unit

Endocrine
Joana Simões-PereiraCarlos Calhaz-Jorge

Abstract

Anti-Müllerian hormone (AMH) is a useful marker of ovarian reserve. Obesity/overweight are increasing and may affect the reproductive health. Previous studies regarding the effect of body mass index (BMI) on AMH levels are discordant. Our main goal was to evaluate the influence of BMI on AMH levels in women without polycystic ovarian syndrome. Revision of medical records of 951 women who performed AMH determinations as part of their fertility workup, between 2011 and 2016. Median AMH concentration was 1.75 [interquartile range (IQR) 2] ng/mL (12.9 pmol/mL) and median age at AMH determination was 35 (IQR 6) years. These women evidenced a median BMI of 23 (IQR 5) kg/m2. Caucasian women were more represented [889(89.3%)]. Smoking habits (present/past) were present in 359(36.1%), and 147(14.8%) harboured a history of ovarian surgery. On univariable analysis AMH was not correlated with BMI (r = 0.048/p = 0.135); the only factors influencing AMH were age (p < 0.001), ethnicity (p = 0.004), and previous ovarian surgery (p < 0.001). On multivariable analysis, age was the only variable significantly associated with AMH, evidencing a reduction of 6.2% for each additional year (p < 0.0001). Furthermore, we verified a trend suggesting an A...Continue Reading

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Citations

Feb 19, 2020·Clinical Chemistry and Laboratory Medicine : CCLM·Osman EvliyaogluJosef van Helden
Feb 23, 2020·Thyroid : Official Journal of the American Thyroid Association·Marloes NiesThera P Links
Jun 25, 2020·Reproductive Sciences·Shanlee M DavisNicole R Tartaglia
Apr 2, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Yu RanCong Li
Aug 25, 2021·Climacteric : the Journal of the International Menopause Society·J ZhangW Bai

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