Influence of body mass index on the relationship between endometrial thickness and pregnancy outcome in single blastocyst frozen embryo transfer cycles

Human Fertility : Journal of the British Fertility Society
David CrosbyMary Wingfield

Abstract

To date there is limited published data assessing whether body mass index (BMI) influences endometrial thickness (ET) and whether this impacts on pregnancy outcomes in single blastocyst FET cycles. The objective of this study, therefore, was to examine the relationship between BMI and ET on the outcome of single blastocyst FET cycles over a five-year period from 2012 until 2016. Patient age, BMI, endometrial pattern and ET prior to FET were recorded. Pregnancy outcomes included: implantation rate, clinical pregnancy rate and live birth rate. A total of 464 cycles met the inclusion criteria and the female age was 36.0 ± 3.0 years (mean ± SD). The mean ± SD BMI was 23.3 ± 3.1 kg/m2 and median ± SD ET was 8.1 ± 1.5 mm. BMI and ET were modestly correlated (Pearson r = 0.244) and there was an association between higher BMI category and higher median ET (7.2, 8.0, 8.3, 8.9 mm; p < 0.001). However, there was no association between ET and pregnancy outcome, either unadjusted, or adjusted for BMI, age, endometrial pattern or embryo quality. The data suggests that although ET increases with increasing BMI, there are no differences in cycle outcome. Importantly, this implies that an ET <8 mm may not jeopardize pregnancy outcome in women w...Continue Reading

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Citations

Jan 8, 2020·Human Fertility : Journal of the British Fertility Society·Mohammed Al-AqbiNeil Smart
Sep 19, 2020·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Einat Shalom-PazAlon Shrim
Feb 9, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Yiquan XiongXin Sun
Oct 3, 2020·Journal of Gynecology Obstetrics and Human Reproduction·Sima JafarpourRasoul Salehi
Dec 2, 2021·The Journal of Clinical Endocrinology and Metabolism·Xi ShenLi Wang

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