Influence of body mass index on the response to asthma controller agents

The European Respiratory Journal
M Peters-GoldenJ M Edelman

Abstract

The incidence of asthma has been positively associated with obesity. Asthma comprises diverse "phenotypes" reflecting heterogeneity in a number of characteristics, including response to therapy. The present authors examined whether body mass index (BMI) influenced the response to placebo, as well as to two asthma controller medications. A post hoc analysis was performed, pooling data from four double-blind, placebo-controlled studies randomising 3,073 moderate asthmatic adults to montelukast (n=1,439), beclomethasone (n=894) or placebo (n=740). The primary end point was asthma control days; other end points were forced expiratory volume in one second, beta-agonist use and nocturnal awakening. Analyses were conducted using BMI classification into normal (<25.0 kg.m-2; 52% of patients), overweight (25-29.9 kg.m-2; 32%) and obese (>or=30.0 kg.m-2; 16%) categories, as well as BMI as a continuous variable. The treatment groups were balanced for BMI, demographic characteristics and parameters of asthma control. The placebo response for all end points was generally lower with increasing BMI. Similarly, the response to the inhaled corticosteroid decreased, whereas the response to the leukotriene antagonist remained stable. In conclusio...Continue Reading

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Citations

Oct 6, 2007·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Oren ShavitStephanie D Taylor
Apr 27, 2013·Current Allergy and Asthma Reports·Shyamala PradeepanAnne E Dixon
Jun 30, 2009·Advances in Therapy·Jean BousquetMarc Humbert
May 21, 2013·Biochemical Pharmacology·Astrid Stefanie KahntThorsten Jürgen Maier
Jan 6, 2009·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Daniel WaggonerThomas B Casale
Nov 6, 2007·The New England Journal of Medicine·Marc Peters-Golden, William R Henderson
Mar 7, 2009·The New England Journal of Medicine·Christopher H Fanta
Jul 7, 2012·Pediatric Allergy, Immunology, and Pulmonology·Jason E Lang
Nov 9, 2006·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Niranjan Kissoon
Nov 17, 2009·Current Opinion in Allergy and Clinical Immunology·Teal S Hallstrand, William R Henderson
Nov 30, 2006·Current Opinion in Pulmonary Medicine·Stephanie A Shore
Dec 17, 2008·Current Opinion in Pulmonary Medicine·Leif Bjermer, Zuzana Diamant
Oct 31, 2009·Current Opinion in Pulmonary Medicine·Esther L Langmack, Richard J Martin
Jun 23, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Vanessa M McDonaldPeter G Gibson
Oct 14, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Claude S Farah, Cheryl M Salome
Oct 31, 2009·Journal of Applied Physiology·Stephanie A Shore
Oct 31, 2009·Journal of Applied Physiology·Peter Mancuso
Oct 31, 2009·Journal of Applied Physiology·Njira L LugogoAnne E Dixon
Jan 20, 2007·American Journal of Respiratory and Critical Care Medicine·David A Beuther, E Rand Sutherland
Jul 21, 2007·American Journal of Respiratory and Critical Care Medicine·Richard A JohnstonStephanie A Shore
Feb 12, 2008·American Journal of Respiratory and Critical Care Medicine·Tim J T SutherlandD Robin Taylor
May 16, 2008·American Journal of Respiratory and Critical Care Medicine·Pranab HaldarRuth H Green
Jul 19, 2008·American Journal of Respiratory and Critical Care Medicine·E Rand SutherlandDonald Y M Leung
Jan 16, 2010·American Journal of Respiratory and Critical Care Medicine·E Rand SutherlandDonald Y M Leung
Jan 24, 2012·American Journal of Respiratory and Critical Care Medicine·Kelly Wong McGrathUNKNOWN Asthma Clinical Research Network of the National Heart, Lung, and Blood Institute
Jul 28, 2012·American Journal of Respiratory and Critical Care Medicine·Olga SidelevaAnne E Dixon
Sep 4, 2012·American Journal of Respiratory and Critical Care Medicine·Anne E Dixon
Jan 1, 2011·Therapeutic Advances in Chronic Disease·Pierluigi Paggiaro, Elena Bacci
Nov 3, 2010·Respiratory Research·Foteini MalliZoe Daniil
Nov 28, 2012·Respiratory Research·Cheng YuanXin Yao
May 19, 2012·PloS One·E Rand SutherlandUNKNOWN Asthma Clinical Research Network
Dec 18, 2010·American Journal of Public Health·Sandra Crouse QuinnKelley Kidwell
Sep 13, 2013·Nutrients·Hashim A PeriyalilLisa G Wood
Jan 1, 2008·Lung India : Official Organ of Indian Chest Society·Pr Gupta
Aug 24, 2013·Journal of Allergy·Bill Brashier, Sundeep Salvi
Jul 5, 2013·American Journal of Respiratory and Critical Care Medicine·Jacob P Scott, Marc Peters-Golden
Feb 25, 2014·Annals of the American Thoracic Society·Nicolas RocheUNKNOWN Respiratory Effectiveness Group
May 11, 2013·Lung India : Official Organ of Indian Chest Society·Pranab Baruwa, Kripesh Ranjan Sarmah
May 28, 2013·Journal of Allergy·Shannon NovosadAkram Khan
Jan 10, 2013·Contemporary Clinical Trials·Jason E LangUNKNOWN Nemours Network for Asthma Research
May 16, 2009·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·A DeschildreJ de Blic

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