Influence of CA125, platelet count and neutrophil to lymphocyte ratio on the immune system of ovarian cancer patients

Gynecologic Oncology
Thaïs BaertAn Coosemans

Abstract

The effect of CA125, neutrophil to lymphocyte ratio (NLR) and thrombocytosis on survival has been studied in ovarian cancer. This study explores the link between these variables and serum markers of ovarian cancer patients, such as signaling proteins and cytokines. Serum samples of 39 patients with high-grade serous ovarian cancer (HGSOC) were collected at diagnosis and were retrospectively analysed for clinical characteristics, clinical parameters (NLR, CA125, platelet count) and immune profile [IL-4 (interleukin), IL-10, IL-13, IL-17, transforming growth factor-β, Arginase-1, Interferon gamma), vascular endothelial growth factor (VEGF), galectin-1 and chemokine (C-C) motif ligand 2. CA125 correlates negatively with VEGF (p = 0.02) and if CA125 rises above 500 kU/L, IL-10 is significantly increased (p = 0.01). NLR > 6 (p < 0.01) was significantly correlated with decreased overall survival. Thrombocytosis was significantly correlated with IL-10 (p < 0.01) and a platelet count > 400 × 109/l led to an improvement in progression free survival (p < 0.01). A correlation, at the time of diagnosis, of HGSOC between CA125, NLR and thrombocytes and an immunosuppressive cytokine-profile in serum is shown, and correlates with survival.

Citations

Oct 2, 2019·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Lina SalmanRam Eitan
Jul 26, 2019·BioMed Research International·Hongyan ZhangHuijing Bao
Jan 8, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Joseph CarmichealSurinder K Batra
Jan 10, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Minghai ZhangYu Wang
May 29, 2021·Scientific Reports·Claudia MarchettiAnna Fagotti

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