PMID: 9170342May 1, 1997Paper

Influence of caffeine and caffeine withdrawal on headache and cerebral blood flow velocities

Cephalalgia : an International Journal of Headache
E G CouturierH van Duijn

Abstract

Caffeine consumption may cause headache, particularly migraine. Its withdrawal also produces headaches and may be related to weekend migraine attacks. Transcranial Doppler sonography (TCD) has shown changes in cerebral blood flow velocities (BFV) during and between attacks of migraine. In order to examine whether headache and changes in BFV could develop from controlled caffeine alterations, 20 healthy volunteers without a headache history, underwent clinical evaluation, TCD and serum caffeine measurements on four occasions, comparing conditions of regular caffeine intake, caffeine withdrawal and "re-caffeination". After 24 h of complete caffeine abstinence, 10 suffered from moderate to severe headaches with complete recovery within 1 h after caffeine intake. The BFVs in both middle cerebral, both posterior cerebral and basilar arteries were higher following the withdrawal period, reaching statistical significance in the left middle cerebral basilar and both posterior cerebral arteries. BFVs decreased significantly within half an hour after caffeine intake in all subjects, and were similar to baseline values after 2 h. Our results emphasize the relationship between caffeine withdrawal, the development of headache and alteration...Continue Reading

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Citations

Jul 16, 2008·Current Pain and Headache Reports·Robert E Shapiro
May 4, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Claus G HaaseGeorg Wensing
Jun 6, 2000·Pharmacology, Biochemistry, and Behavior·J M WatsonD Kerr
Mar 12, 1999·Neuroscience and Biobehavioral Reviews·A Nehlig
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Jun 4, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Peter J RogersDavid J Nutt
Jul 28, 2001·Diabetes Technology & Therapeutics·J Watson, D Kerr
Mar 23, 2007·Cephalalgia : an International Journal of Headache·K B AlstadhaugS Bekkelund
Sep 17, 2008·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Norbert CibicekVladimir Palicka
Feb 24, 2016·Expert Review of Neurotherapeutics·Brian Edwin Cairns
Jul 4, 2012·Annals of Human Biology·Angela RezaDaniel E Brown
Oct 27, 2017·The Journal of Headache and Pain·Richard B LiptonKetu Patel
Jul 7, 2016·Cephalalgia : an International Journal of Headache·Mi Ji LeeChin-Sang Chung
Feb 17, 2009·Human Brain Mapping·Merideth A AddicottPaul J Laurienti
Mar 13, 2019·Human Psychopharmacology·Laura M JulianoKathryn C Edwards
Oct 5, 2016·Headache·Vincent T Martin, Brinder Vij
Dec 19, 2019·Frontiers in Neurology·Karl B Alstadhaug, Anna P Andreou
Aug 1, 2020·Nutrients·Magdalena NowaczewskaWojciech Kaźmierczak
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Oct 5, 2016·Headache·Vincent T Martin, Brinder Vij
Oct 21, 2020·Headache·Kai ZhuEsma Dilli
Feb 20, 2021·Frontiers in Neurology·Umberto RaucciPasquale Parisi
May 2, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Matthew S Agritelley, Jeffrey J Goldberger
Feb 19, 2009·Medical Hypotheses·J R IflandG Manso

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