Influence of Caffeine Consumption by Pregnant Rats on Behavior and Learning in Their Offspring

Bulletin of Experimental Biology and Medicine
V G BashkatovaS K Sudakov

Abstract

We studied the effect of long-term prenatal administration of caffeine on the behavior and learning of rats in postnatal ontogeny. Experiments were carried out on male rats born by females receiving caffeine solution as the only source of fluid throughout gestation. The control group consisted of pups obtained from females receiving drinking water throughout pregnancy. It was found that long-term caffeine intake by female rats during pregnancy determined increased locomotor activity of the offspring. Rat pups born from mothers treated with caffeine during pregnancy faster reached the underwater platform in the Morris maze, i.e. demonstrated better spatial memory formation than control animals.

References

Mar 1, 1996·Neurotoxicology and Teratology·K D Acuff-SmithC V Vorhees
Aug 3, 2002·Bulletin of Experimental Biology and Medicine·S K SudakovI B Figurina
Nov 16, 2006·Annals of the New York Academy of Sciences·Valentina BashkatovaTangui Maurice
Jan 24, 2009·Physiology & Behavior·Valerie B ThompsonJack W Lipton
Aug 19, 2009·Behavioural Brain Research·Deborah E SoellnerJoseph L Nuñez
Feb 7, 2012·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Michael D Moenk, Leslie Matuszewich
Jan 15, 2013·Clinical Obstetrics and Gynecology·Michael K Lindsay, Erin Burnett

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