PMID: 6107366Sep 1, 1980Paper

Influence of calcium on noradrenaline release evoked by 5-hydroxytrypamine and potassium from goat pial arteries

The Journal of Pharmacy and Pharmacology
J Marín, C F Sánchez

Abstract

The release of tritium (3H) evoked by tyramine, potassium (K+) and 5-hydroxytryptamine (5-HT) from goat pial arteries preloaded with [3H]noradrenaline (3H-NA) was studied. In normal Krebs-bicarbonate solution (KBS) all these agents caused a transient increase in radioactivity release over the basal spontaneous outflow. The pattern of release evoked by 5-HT was similar to that induced by tyramine with a slow onset and decline, but different from that induced by K+ which produced a rapid peak of 3H release followed by a quick fall. The removal of Ca2+ from the medium did not modify the efflux of radioactivity caused by tyramine, but the 3H efflux produced by K+ was markedly reduced. Nevertheless, in this Ca2+-free medium the 3H release evoked by 5-HT was partially, but significantly, decreased. These results indicate that K+ evokes NA release by a Ca/+-dependent process, probably of an exocytotic nature, while tyramine mediates NA release by means of a Ca2+-independent mechanism. However, 5-HT possesses a Ca2+-dependent and a tyramine-like component.

References

Dec 1, 1979·The Journal of Pharmacy and Pharmacology·J MarinC F Sánchez
Jun 15, 1978·European Journal of Pharmacology·F Riccioppo Neto
Oct 16, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·K Starke, R Weitzell
Oct 1, 1976·The Journal of Physiology·A G GarciaP Sanchez-Garcia
Oct 1, 1971·Acta Physiologica Scandinavica·G FillionB Uvnäs
Jan 1, 1972·Naunyn-Schmiedeberg's Archives of Pharmacology·I W ChubbA F De Schaepdryver
Apr 1, 1969·European Journal of Pharmacology·H ThoenenW Haefely

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Citations

Jan 1, 1982·General Pharmacology·J Marín, F Rivilla
Jan 1, 1991·General Pharmacology·M J Garcia de BotoA Hidalgo
Jan 1, 1997·Journal of Basic and Clinical Physiology and Pharmacology·B Adegunloye, O Sofola
Dec 1, 1985·Agents and Actions·J A MadridF J Mataix
Jun 1, 1990·Agents and Actions·J A ParienteJ A Madrid
Apr 1, 1989·British Journal of Pharmacology·J Reviriego, J Marín
Dec 1, 1982·British Journal of Pharmacology·D W Hay, R M Wadsworth
Apr 1, 1984·The Journal of Pharmacy and Pharmacology·G BalfagónE J Marco

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