Influence of cancer-related gene polymorphisms on clinicopathological features in colorectal cancer

Journal of Gastroenterology and Hepatology
Gen YoshiyaShinsaku Fukuda

Abstract

Single nucleotide polymorphisms (SNP) are shown to be related with cancer incidence. It has been reported that CCND1, p21(cip1)DCC, MTHFR, and EXO1 are related with the risk of malignant neoplasm, but few studies have mentioned the prognosis of the patients. We investigated the SNP of patients and related this to clinicopathological features, including survival rate. DNA from the tissues of primary colorectal cancer was obtained from surgical resections of 114 patients (68 males and 46 females, 29-83 years). The CCND1 polymorphism was analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and those of other genes were investigated by the TaqMan method. The polymorphisms obtained were statistically analyzed for the relationship with clinicopathological features. The CG + GG allele was more invasive than the CC allele in histological tumor depth in the DCC codon 201 (P = 0.0086). The 677TT allele in MTHFR had a larger tumor size than the 677CC allele (P = 0.028). In EXO1 P757L polymorphism, patients with the TT allele had a statistically reduced survival rate compared with the other alleles. In CCND1 polymorphisms, we found no statistical significance in clinicopathological features. From these ...Continue Reading

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Citations

Feb 10, 2009·Journal of the American Chemical Society·Yun Suk HuhDavid Erickson
Apr 10, 2010·BMC Bioinformatics·Hsueh-Wei ChangCheng-Hong Yang
Jun 15, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Manzoor Ahmad MalikBalraj Mittal
Dec 15, 2010·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Hongxia MaYongqian Shu
Jun 21, 2008·Journal of Gastroenterology and Hepatology·Vicki Whitehall, Barbara Leggett

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