Influence of carbon nanomaterial defects on the formation of protein corona

RSC Advances
Bishwambhar SenguptaR Podila

Abstract

In any physiological media, carbon nanomaterials (CNM) strongly interact with biomolecules leading to the formation of biocorona, which subsequently dictate the physiological response and the fate of CNMs. Defects in CNMs play an important role not only in material properties but also in the determination of how materials interact at the nano-bio interface. In this article, we probed the influence of defect-induced hydrophilicity on the biocorona formation using micro-Raman, photoluminescence, infrared spectroscopy, electrochemistry, and molecular dynamics simulations. Our results show that the interaction of proteins (albumin and fibrinogen) with CNMs is strongly influenced by charge-transfer between them, inducing protein unfolding which enhances conformational entropy and higher protein adsorption.

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Citations

Jun 10, 2016·ACS Applied Materials & Interfaces·Sai Sunil Kumar MallineniRamakrishna Podila
Sep 11, 2020·Biotechnology and Applied Biochemistry·Maria NicolettiElisa Fasoli
Feb 23, 2019·Soft Matter·Siva DasettySapna Sarupria
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Apr 3, 2018·Nanotechnology Reviews·Jonathan Shannahan
Mar 1, 2019·Advanced Biosystems·Khurram S MunirYuncang Li
Mar 5, 2021·The Journal of Physical Chemistry. B·Siva Dasetty, Sapna Sarupria
Jul 2, 2021·Journal of Advanced Research·Antonio Juárez-MaldonadoAdalberto Benavides-Mendoza
Jul 25, 2021·International Journal of Molecular Sciences·Fabio VianelloMassimiliano Magro
Jan 9, 2021·ACS Applied Materials & Interfaces·Sachin Kumar, Sapun H Parekh

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