PMID: 8471379Mar 1, 1993Paper

Influence of cardiac output, injection time and injection volume on the initial mixing of drugs with venous blood after i.v. bolus administration to sheep

British Journal of Anaesthesia
R N Upton, Y F Huang

Abstract

The aim of this study was to quantitate factors affecting the initial "peak" of the pulmonary artery (PA) drug concentrations after i.v. bolus drug administration, which is a determinant of the subsequent drug uptake into both the lungs and other well-perfused organs. Indocyanine green (ICG) was used as a marker drug in anaesthetized (1.5% halothane) sheep prepared with an inferior vena cava injection catheter and a large-gauge pulmonary artery blood sampling catheter. For three ranges of cardiac output, 2.5-mg doses of ICG were injected in the following combinations: 10 ml injected over 1, 5 or 10 s; 5 or 25 ml injected over 1 s. On-line PA ICG concentrations were recorded for approximately 60 s using a densitometer. The mean maximum PA ICG concentrations (2-8 mg litre-1), the mean times at which they occurred (7-18 s after injection) and the time lags before ICG was detected in the PA (4-9 s), were inversely related to cardiac output, but linearly related to the time over which the injection was made. The area under the curve of the peak was related inversely to cardiac output only, while the aspect ratio of the peak was related inversely to the time over which the injection was made only. The injectate volume had no effect o...Continue Reading

Citations

Feb 24, 2001·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·S YamaguchiT Kitajima
Dec 1, 1994·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·H IwasakiA Namiki
May 1, 1997·Experimental Gerontology·H HarashimaD R Stanski
Jul 1, 1999·Clinical and Experimental Pharmacology & Physiology·R N Upton, D J Doolette
Jul 21, 2005·Regional Anesthesia and Pain Medicine·Frédéric Aubrun
May 11, 2007·Best Practice & Research. Clinical Anaesthesiology·Frédéric Aubrun, Frédéric Marmion
Aug 1, 2009·Equine Veterinary Journal·J A E HubbellW W Muir
May 1, 1996·Research in Veterinary Science·Y F HuangA J Rutten
Nov 22, 2005·Veterinary Anaesthesia and Analgesia·Alexandra H A DugdaleWendy A Adams
Dec 26, 2001·Anesthesiology·Frédéric AubrunBruno Riou
Jun 27, 2003·Anesthesiology·Frédéric AubrunBruno Riou
Apr 17, 2004·Anesthesiology·Martijn J MertensJaap Vuyk
Jul 28, 1999·Anesthesiology·T D EganP L Bailey
Apr 1, 1996·Journal of Pharmaceutical Sciences·J M GriesD Verotta

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