PMID: 9179261May 1, 1997Paper

Influence of cathepsin D expression in lung adenocarcinoma on prognosis: possible importance of its expression in tumor cells and stromal cells, and its intracellular polarization in tumor cells

Journal of Surgical Oncology
M HigashiyamaS Ishiguro

Abstract

Cathepsin D, an aspartic lysosomal proteinase, has been described to be closely associated with tumor progression and prognosis in some human malignancies. The purpose of this study was to determine clinicopathological and prognostic significance of cathepsin D expression in lung adenocarcinoma. Expression of cathepsin D in 152 lung adenocarcinoma patients was immunohistochemically studied using the antihuman cathepsin D antibody. Eighty patients (53%) showed negative immunoreactivities in tumor cells. The cathepsin D-positive patients (72 patients, 47%) were divided into two subgroups; granular type expression (48 patients, 31%) with its polarized expression mainly in the luminal side of the cytoplasm of tumor cells and basal type expression (24 patients, 16%) with its polarized expression mainly in the basal or infranuclear side of the cytoplasm. Patients with basal type expression showed significantly more marked scar formation (P = 0.042), and especially among the patients with stage I disease, those with basal type tended to show poorer prognosis (P = 0.071) than the others. Cathepsin D was also expressed in stromal cells within the tumor tissues, and 86 patients (57%) with moderate to massively infiltrating cathepsin D-po...Continue Reading

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Citations

Apr 8, 2006·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Silvia CernáSona Wimmerová
Jul 25, 2012·Pathology, Research and Practice·Takahiro MimaeHitoshi Tsuda
Feb 8, 2005·Clinical Lung Cancer·Peyman Sardari NiaPaul Van Schil
Sep 13, 2002·Chest·Michael D BrundageWilliam J Mackillop
May 3, 2016·Veterinary and Comparative Oncology·L H Pulz, R F Strefezzi

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