PMID: 7543211Jul 1, 1995Paper

Influence of CD14, LBP and BPI in the monocyte response to LPS of different polysaccharide chain length

Scandinavian Journal of Immunology
T G JahrTerje Espevik

Abstract

In this study we examined the involvement of human serum, recombinant lipopolysaccharide binding protein (rLBP), recombinant (r)CD14, CD14 antibodies and recombinant bactericidal permeability-increasing factor (rBPI) in the induction of TNF by Salmonella minnesota LPS of different polysaccharide chain lengths. Soluble rCD14 and rLBP markedly enhanced LPS 6261 TNF production and to a lesser degree also enhanced TNF production from Re 595 LPS and lipid A DP. Addition of anti-CD14 antibodies resulted in nearly complete inhibition of LPS 6261-induced TNF production and partial inhibition of Re 595 LPS and lipid A DP-induced TNF release. The ability of lipid A MP to induce TNF production increased with addition of rCD14. Addition of rLBP or anti-CD14 antibodies had no detectable effect on lipid A MP-induced TNF production. The effect of rBPI was also tested and the results showed that only the TNF-inducing ability from smooth LPS was completely inhibited by rBPI. Recombinant BPI was considerably less effective in inhibiting Re 595 LPS-induced TNF production, and lipid A DP was not affected by rBPI. Our data suggest that the ability of rLBP, rCD14, CD14 antibodies and rBPI to modulate LPS induced TNF production is strongly dependent ...Continue Reading

References

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Citations

Mar 23, 2000·European Journal of Biochemistry·A B SchrommU Seydel
Jul 14, 2010·Biochemistry. Biokhimii︠a︡·D S Kabanov, I R Prokhorenko
Feb 22, 2001·Annual Review of Physiology·E Crouch, J R Wright
Sep 24, 2005·Health Services Research·Mildred RamírezJeanne A Teresi
Mar 20, 2016·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Sonja T H M KolanowskiAnja Ten Brinke
May 16, 1998·The Journal of Biological Chemistry·R DziarskiP S Tobias
Jul 31, 2003·Journal of Biomedical Materials Research. Part a·Sylvie Anastase-RavionDidier Letourneur
Nov 19, 2003·Scandinavian Journal of Infectious Diseases·Terje EspevikDouglas T Golenbock
Oct 30, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ruth HuizingaBart C Jacobs

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