Influence of cell-free Hb on local tissue perfusion and oxygenation in acute anemia after isovolemic hemodilution

Transfusion
A G Tsai

Abstract

Oxygen-carrying solutions are intended to eliminate the blood transfusion trigger. Their ability to maintain microvascular perfusion and to deliver oxygen to tissue when they replace the RBCs as oxygen carriers has not been directly measured. Microvascular response to exchange transfusion with a polymerized bovine cell-free Hb (PBH) solution after acute isovolemic hemodilution with a plasma expander was investigated by using the hamster window model. In vivo functional capillary density (FCD), blood flow, and high-resolution oxygen distribution in microvascular networks were measured by noninvasive methods. Exchange transfusion of PBH solution after a 60-percent isovolemic hemodilution with dextran 70 (MW, 70 kDa) resulted in a Hct of 11 percent and a Hb content of 6.7 g per dL. FCD was 0.37 of baseline. Interstitial pO2 was reduced from 21.0 mm Hg to 0.3 mmHg. Arteriolar and venular blood flows were ratios of 0.75 and 0.76 relative to baseline. In a previous study, tissue pO2 after hemodilution to 5.6 g of Hb per dL with dextran 70 was 23.0 mmHg. Hypervolemic injection of PBH solution increased blood pressure and caused vasoconstriction. Using PBH solution to replace RBC oxygen-carrying capacity during low Hb content condition...Continue Reading

References

Sep 1, 1975·Microvascular Research·M IntagliettaW R Tompkins
Jan 1, 1992·Advances in Experimental Medicine and Biology·K WagnerU Schramm
Nov 1, 1986·Circulation Research·P C Johnson
Jan 1, 1986·Annals of Biomedical Engineering·D A GoughP H Tse
May 1, 1973·Microvascular Research·M Intaglietta, W R Tompkins
Jan 1, 1980·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·B EndrichK Messmer
Oct 19, 1995·The New England Journal of Medicine·L GattinoniR Fumagalli
Jul 1, 1996·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·T StandlJ Schulte am Esch
Nov 1, 1996·World Journal of Surgery·U Kreimeier, K Messmer
Feb 1, 1997·The American Journal of Physiology·G WalterJ S Leigh
Nov 14, 1997·American Journal of Respiratory and Critical Care Medicine·A W SielenkämperW J Sibbald
Jun 17, 1998·Proceedings of the National Academy of Sciences of the United States of America·A G TsaiM Intaglietta
Mar 12, 1999·Annual Review of Medicine·R M Winslow
Mar 29, 2001·Anesthesia and Analgesia·A A AliA P Shepherd

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Mar 11, 2005·The Protein Journal·M Zouhair Atassi, Catherine Childress
Nov 19, 2004·Antioxidants & Redox Signaling·Amy G TsaiMarcos Intaglietta
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Jul 13, 2006·Annual Review of Biomedical Engineering·Marcos IntagliettaAmy G Tsai
Jul 23, 2004·Expert Opinion on Biological Therapy·Amy G TsaiMarcos Intaglietta
Aug 10, 2007·Journal of Theoretical Biology·Nikolaos M TsoukiasAleksander S Popel
Apr 19, 2003·Journal of Internal Medicine·L-H Yeh, A I Alayash
Sep 18, 2012·Life Sciences·Jacob ElmerPedro Cabrales
Feb 21, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Pedro CabralesMarcos Intaglietta
Jun 12, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Pedro CabralesMarcos Intaglietta
Jun 12, 2004·American Journal of Physiology. Heart and Circulatory Physiology·B FrieseneckerM Intaglietta
Jun 24, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Pedro CabralesMarcos Intaglietta
Aug 7, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Pedro CabralesMarcos Intaglietta
Nov 26, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Nanae Hangai-HogerMarcos Intaglietta
Nov 26, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Pedro CabralesMarcos Intaglietta
Dec 14, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Pedro CabralesMarcos Intaglietta
Jan 8, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Pedro CabralesMarcos Intaglietta
Dec 31, 2005·Journal of Applied Physiology·Pedro CabralesMarcos Intaglietta
Mar 7, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Pedro CabralesAmy G Tsai
May 30, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Pedro Cabrales, Amy G Tsai
Apr 25, 2007·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·Anthony T W CheungRobert A Gunther
Jun 9, 2007·Journal of Applied Physiology·Gregory M T HareAndrew J Baker
Jul 24, 2008·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·Peter C Y ChenAnthony T W Cheung
Nov 15, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Juan Carlos BriceñoMarcos Intaglietta
Jan 21, 2003·Journal of Applied Physiology·Gregory M T HareAndrew J Baker
Jan 29, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Jing ZhaoHongli Zhu
Sep 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Ann L BaldwinAbdu I Alayash
Jun 4, 2004·The Biochemical Journal·Kim D VandegriffRobert M Winslow
Feb 15, 2002·Current Opinion in Hematology·Robert M Winslow
Jul 19, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Pedro CabralesMarcos Intaglietta
Jul 5, 2003·Physiological Reviews·Amy G TsaiMarcos Intaglietta
Aug 30, 2002·The New England Journal of Medicine·Jean-François HardyPhilippe Van der Linden

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