PMID: 41029Sep 1, 1979

Influence of cerebral embolism on brain monoamines

Journal of Neurology, Neurosurgery, and Psychiatry
N IshiharaA Miyakawa


In baboons the right cerebral hemisphere was embolised by a shower of microemboli, immediately followed by one large embolus designed to occlude the middle cerebral artery (MCA). One hour after embolism a significant, though small, reduction in blood flow and oxygen consumption of the embolised hemisphere was recorded, at which time the animals were killed and brain monoamines measured. Dopamine was reduced in the ipsilateral caudate nucleus, the reported site of maximal ischaemic damage in this model. Dopamine levels were increased in frontal and occipital grey matter sampled from areas surrounding the occluded MCA territory and in similar brain areas of the opposite non-embolised hemisphere. Noradrenaline was increased in grey matter from both cerebral hemispheres, as well as subcortical structures bilaterally. Brain 5-hydroxytryptamine levels were unaltered, but increased 5-hydroxyindoleacetic acid in cisternal cerebrospinal fluid suggested transient alteration in 5-hydroxytryptamine metabolism after embolism. The effects of cerebral embolism on brain monoamine metabolism appear to be different from the effects of permanent surgical occlusion of major cerebral vessels. The bilaterality of effects after unilateral hemispheric...Continue Reading


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Jan 22, 2003·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M D CisterninoE Vittoria

Related Concepts

Insula of Reil
Cerebral Embolism and Thrombosis
Homovanillic Acid
Hydroxyindoleacetic Acid

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