PMID: 41029Sep 1, 1979

Influence of cerebral embolism on brain monoamines

Journal of Neurology, Neurosurgery, and Psychiatry
N IshiharaA Miyakawa

Abstract

In baboons the right cerebral hemisphere was embolised by a shower of microemboli, immediately followed by one large embolus designed to occlude the middle cerebral artery (MCA). One hour after embolism a significant, though small, reduction in blood flow and oxygen consumption of the embolised hemisphere was recorded, at which time the animals were killed and brain monoamines measured. Dopamine was reduced in the ipsilateral caudate nucleus, the reported site of maximal ischaemic damage in this model. Dopamine levels were increased in frontal and occipital grey matter sampled from areas surrounding the occluded MCA territory and in similar brain areas of the opposite non-embolised hemisphere. Noradrenaline was increased in grey matter from both cerebral hemispheres, as well as subcortical structures bilaterally. Brain 5-hydroxytryptamine levels were unaltered, but increased 5-hydroxyindoleacetic acid in cisternal cerebrospinal fluid suggested transient alteration in 5-hydroxytryptamine metabolism after embolism. The effects of cerebral embolism on brain monoamine metabolism appear to be different from the effects of permanent surgical occlusion of major cerebral vessels. The bilaterality of effects after unilateral hemispheric...Continue Reading

References

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Citations

Jan 1, 1985·Journal of Neurology·K HegedüsL Molnár
Mar 1, 1992·Microvascular Research·D R TheodoreJ Abraham
Jul 1, 1983·Stroke; a Journal of Cerebral Circulation·J A Zivin, J Stashak
Dec 1, 1988·Stroke; a Journal of Cerebral Circulation·T KawanoK Mori
Sep 1, 1980·Stroke; a Journal of Cerebral Circulation·J D Easton, D G Sherman
Aug 1, 1988·Stroke; a Journal of Cerebral Circulation·J L Halperin, R G Hart
Jan 1, 1980·Neurological Research·J S MeyerD Armstrong
Jul 24, 2018·Frontiers in Synaptic Neuroscience·Annette Gower, Mario Tiberi
Jan 22, 2003·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M D CisterninoE Vittoria

Related Concepts

Metazoa
Anthropoidea
Insula of Reil
Cerebral Embolism and Thrombosis
Homovanillic Acid
Hydroxyindoleacetic Acid
Papio
Hydroxytryptamine
Neurosteroids

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