PMID: 9176083Apr 1, 1997Paper

Influence of changes in pancreatic tissue morphology and capillary blood flow on antibiotic tissue concentrations in the pancreas during the progression of acute pancreatitis

Gut
T FoitzikH J Buhr

Abstract

The ability of an antibiotic to reach bactericidal concentrations in tissue depends on numerous factors including tissue composition and regional perfusion. Although necrotising pancreatitis is characterised by progression of pancreatic necrosis over at least 96 hours and microcirculatory alterations, the impact of these changes on the concentration of antibiotics in the pancreas has not yet been investigated. To determine and compare pancreatic tissue concentrations of imipenem and cefotaxime at different stages of acute necrotising pancreatitis in an animal model that has been shown to mimic closely the pathomorphological and bacteriological features of severe human pancreatitis. Acute necrotising pancreatitis was induced in rats by a standardised intraductal infusion of glycodeoxycholic acid and intravenous cerulein. Six hours (n = 16) and 48 hours (n = 16) after induction of pancreatitis, the animals were randomised for intravenous therapy with either imipenem or cefotaxime. Fifteen minutes after injection of the antibiotic, the animals were killed. Blood and the head of the pancreas were collected for determining imipenem or cefotaxime in serum and tissue; the splenic portion of the pancreas was prepared for histological e...Continue Reading

Citations

Feb 27, 2003·Pancreas·Beat GloorMarkus W Büchler
Sep 26, 2003·Pancreas·Umit AteskanIsmail Hakki Kocar
Oct 4, 2003·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Esref CinarKemal Altinatmaz
May 20, 2015·Expert Review of Gastroenterology & Hepatology·Vikesh K SinghEnrique de-Madaria
Apr 8, 2003·Journal of Chemotherapy·D PapagorasH Giamarellou
Aug 16, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Therese KoalVolkhard Kaever
Apr 25, 2000·The Journal of Hospital Infection·A O Qamruddin, P R Chadwick
Jul 4, 1998·The British Journal of Surgery·J J PowellA K Siriwardena
Sep 18, 2008·The American Journal of Gastroenterology·Yoshihisa Tsuji, Tsutomu Chiba
May 14, 2010·The Cochrane Database of Systematic Reviews·Eduardo VillatoroMike Larvin

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